Current Curriculum Molecular Biotechnology

Lecture SWS ECTS
English: The Language of Science ILV

English: The Language of Science ILV

Lector: Dr.in Mary Grace Wallis, FH-Prof. Dr. Paul Watson

2 SWS
2 ECTS

Lecture contents

The timetable for this semester will be provided as detailed information sheets and will be discussed during the first lesson.

See also below (Objective of the course).

Assessment methods

Your command of English, both spoken and written, will be continuously assessed during the semester and will be reflected in the final semester mark. Moreover your active participation in the lessons will also contribute to the overall mark.

Teaching methods

Spontaneous and prepared presentations. Brainstormings, Discussions, Debates. ‘Language clinics’. Individual, pair- and group-work.

Language

English

2 2
Entrepreneurship and Start-ups ILV

Entrepreneurship and Start-ups ILV

Lector: DI Franz Gatterer, MBA

2 SWS
2 ECTS

Lecture contents

Content of a Businessplan (description of business case)
- product and/or service
- market anaylses
- marketing
- management and key/core kompetences needed
- SWOT as bases of decisions
- planning of implementation
- investment required

Assessment methods

Evaluation of group results (written businessplan). On top of this, individual interviews with students about their results allow to adjust quality on an individual level.

Teaching methods

Groupwork: Students develop businessplan according standard model for technology intensive buseinss cases.

Permanent interaction within teams but also between groups.

Language

English

2 2
General Pathology VO

General Pathology VO

Lector: Prim.Univ.Doz. Dr.med. Johann Feichtinger

2 SWS
3 ECTS

Lecture contents

Principles of general pathology including representative examples of organ pathology;
basics in morphology and clinico-pathologic correlations;
nomenclature and systemics of diseases;
methods applied in diagnostic pathology;

Assessment methods

Written multiple choice test

Teaching methods

powerpoint presentations;
manuscript
glossary
mindmaps

Language

English

2 3
Genetic Testing LAB

Genetic Testing LAB

Lector: Ao.Univ.-Prof. Mag. Dr. Dietmar Abraham, Heidi Miedl, Ao.Univ.Prof. Dr. Martin Schreiber, Andrea Steinbauer, BSc MSc, Ao.Univ.Prof.Dr. Rotraud Wieser, Assoz.-Prof. Priv.-Doz. Mag. Dr. Karin Zins

2 SWS
2 ECTS

Lecture contents

Different methods used in genetic analysis are explained and carried out practically. These include the reverse transcriptase polymerase chain reaction for the detection of leukemia associated fusion transcripts, gene amplification and hybridization to immobilized, allele specific oligonucleotides for the detection of mutations in the cystic fibrosis gene, and genotyping of a single nucleotide polymorphism (SNP) in a cohort of patients followed by statistical analysis of the association with disease risk.

Assessment methods

Lab, protocol

Teaching methods

-The theoretical basis of each of the analyses conducted in the lab is explained in a preceding seminar
-Students conduct genetic analyses according to detailed protocol provided by the teachers
-Laboratory results are discussed with teachers at the end of each unit, and are summarized in a protocol whose structure corresponds to that of a scientific paper

Language

English

2 2
Genetic Testing Seminar SE

Genetic Testing Seminar SE

Lector: Ao.Univ.Prof. Dr. Martin Schreiber

1 SWS
1 ECTS

Lecture contents

By critically reading selected key scientific publications, students shall acquire knowledge and understanding of current methods and medical applications of genetic analysis. After an introductory lecture by the lecturer, each participant will work in a small team to present a selected publication from a common topic to the class in a “journal club” format, followed by a detailed discussion by all participants.

Assessment methods

Critical reading and oral presentation of the selected publication(s); Attendance; Active participation in the discussion sessions; Final written exam.

Teaching methods

Introductory lecture by the instructor to the common topic; critical reading of a selected publication, preparation of a powerpoint-presentation of this publication, and oral presentation to the class; Active participation in the discussion of the own presentation and of those of the other participants (“journal club” format). Students have to give their presentation in English.

Language

English

1 1
Genetic Testing VO

Genetic Testing VO

Lector: Univ.-Prof.i.R. Dr. Christine Mannhalter

2 SWS
3 ECTS

Lecture contents

At the end of the lecture
- The students know the basics, the areas of application, and the classical and modern methods of molecular genetics that are currently used in medical diagnostics.
- They will know several diseases where a genetic component is causally involved and will know how to approach its analysis.
- They will be able to differentiate monogenetic from polygenetic and acquired diseases (e.g. cancer) and will be able to decide on the type of analysis.
- They will know how genes are associated with human diseases.

Assessment methods

Preparation of a written manuscript to a specific topic, evaluation of the participation in discussions

Teaching methods

Use of Power Point Presentation, regular discussions, use of quiz

Language

English

2 3
In Silico Biology LAB

In Silico Biology LAB

Lector: Dr.in Anja Friedrich, Mag. Dr. Walter Glaser

3 SWS
3 ECTS

Lecture contents

The course teaches the basics of computer use in modern molecular biology research: search, download and analyze DNA and protein Sequnezen using local and Internet-based resources. Preparation of plasmid and prediction of restriction analysis, genomic resources, GO.
Dealing with literature data, display structures, sequence search (Fasta, Blast)
Databases: NCBI, EBI, PDB, Expasy, OMIM, others

Assessment methods

protocol, Report of Results

Teaching methods

Hands-on Problems

Language

English

3 3
In Silico Biology VO

In Silico Biology VO

Lector: Dr.in Anja Friedrich

1 SWS
2 ECTS

Lecture contents

We will go through specific topics of Bioinformatics and discuss the available applications.
The topics include:
- The Human Genome (Genomanalysis: SNPs, Variant Discovery)
- Biological sequences, sequence comparison
- Biological Databases
- Data Formats
- Protein domains, regulatory patterns
- non-coding RNA prediction
- gene set analysis

Assessment methods

Written test on the theoretical part

Teaching methods

lecture, powerpoint presentation, discussion and hands on exercises

Language

English

1 2
Infection Biology VO

Infection Biology VO

Lector: FH-Prof.in Univ.Doz.in Dr.in Ines Swoboda

1 SWS
2 ECTS

Lecture contents

The lecture deals with the representation of the complex interactions between host and pathogen during infectious diseases. First, the defense mechanisms of the host, the innate and the adaptive immune system, are examined in detail. Then strategies of infection developed by pathogens to overcome host defense, survival and spread are presented. On the basis of model organisms infectious diseases caused by bacteria, viruses, fungi, protozoa and parasites are discussed in more detail. Furthermore, diagnostic and clinical aspects and fundamentals of antimicrobial and antiviral therapy are discussed. Finally, the principles and the most important basic concepts and methods of epidemiology are presented.

Assessment methods

Written exam

Teaching methods

Lecture

Language

English

1 2
Innovation/Knowledge/Technology VO

Innovation/Knowledge/Technology VO

Lector: DI Franz Gatterer, MBA

1 SWS
1 ECTS

Lecture contents

Knowledgemanagement for R&D
- Knowledge definitions "stairs of knowledge"
- Types of Knowledge (Nonaka/Takeuchi /Polanyi)
- Approache of knowledge modelling
- perspectives of KM
- the SECI model and its meaning for R&D
- components of KM
- WEB20 options for KM
- KM and processes of implementation and evaluation

Assessment methods

brief study on R&D KM topics - realized with Mahara platform

Teaching methods

FH-Portal für Sekretariate.htm

Language

English

1 1
Intercultural Teams in Interdisciplinary Projects ILV

Intercultural Teams in Interdisciplinary Projects ILV

Lector: Monika Frauwallner, DI Franz Gatterer, MBA, Dr.in Mary Grace Wallis, FH-Prof. Dr. Paul Watson

1 SWS
1 ECTS

Lecture contents

• Students learn to fully recognize the richness of diversity, to find synergies and to capture and use them.
• Students from different countries, from different cultural backgrounds, from different universities, from different disciplines, of different genders and with individual life experience become acquainted. Through mutual exchange they, and their fellow students, experience those strengths and weaknesses that play a role in their education/profession.
• In a team the requirements of the studies are recognised and developed, compared with the individual’s own strengths and weaknesses and thus, the expertise developed to independently form teams and devise courses of action for specific tasks.

Assessment methods

Active participation

Teaching methods

• Comprehensive principle of systemic thinking.
• Diversity Management.
• Competence-oriented teaching and examination: The students are themselves the focus through collaborating in teams during the teaching of theory and working on problems. While developing their results self-reflection and peer feedback are applied. Methods such as brainstorming, active structuring and discussions (while problem solving and getting to know each other), flashlight (for feedback) and expert interviews are used.
• Knowledge management.
• Team building.
• Project management.
• Transcultural competence

Language

English

1 1
RNA Lab LAB

RNA Lab LAB

Lector: Andrea Steinbauer, BSc MSc, FH-Prof. Dr. Herbert Wank

3 SWS
3 ECTS

Lecture contents

RNA Methods:
Experiment 1: Nothern Blot (Glucose/galactose metabolism in yeast, RNA extraction from yeast, denaturing RNA agarosegel, RNA transfer, specific oligonucleotidehybridazation, band detection)

Experiment 2: EMSA (in vitro transcription with T7 RNA polymerase, RNA purification, RNA folding, native polyacrylgelelectrophoresis, RNA staining with methylblue, detection of the RNP complex)

Experiment 3: RNA stability. The RNA stability is tested by incubation RNA under different conditions. The stability will be analysed by agarose gel electrophoresis.

Assessment methods

The grade combines: Presence, motivation, enthusiasm, practical skills, written protocol.

Teaching methods

Practical Course

Language

English

3 3
RNA VO

RNA VO

Lector: FH-Prof. Dr. Herbert Wank

1 SWS
2 ECTS

Lecture contents

RNA basics, RNA structure, catalytic RNAs, RNA processing, RNA splicing, RNA editing, Riboswitches, RNA applications, Non-coding RNAs, RNA world, SELEX

Assessment methods

wirtten exam at the end of the lecture course

Teaching methods

lecture

Language

English

1 2
Tumour Biology VO

Tumour Biology VO

Lector: Ao. Univ. Prof. Mag. Dr. Jozefa Gadek-Wesierski

2 SWS
3 ECTS

Lecture contents

This course offers an overview on the changes and disturbances of the proper regulation of the cell cycle progression and on the dysfunction of the induction and execution of the programmed cell death which occur during the malignant transformation and finally lead to cancer development. Moreover, it includes the description of the most important post-translational modifications of proteins and their role in the functional regulation of distinct proteins involved in the signal transduction. It gives an understanding of the expression and the function of tumour suppressor genes and proto-oncogenes as well as the changes of their regulation (inhibition or constitutive activation) that essentially contribute to the cancer development.
This course aims at giving students an overall view of the complexity of the carcinogenesis that encompasses cooperation between a variety of changes, dysfunctions and pathways. This course includes several topics depicting the involvement of genetic and external factors in the carcinogenesis. It also gives an understanding of the role and balance between distinct suppressors and oncogenes in the angiogenesis and metastasis.

Assessment methods

Evaluation of regular participation and active cooperation as well as written examination

Teaching methods

lectures

Language

English

2 3

Lecture SWS ECTS
English: The Language of Science ILV

English: The Language of Science ILV

Lector: Dr.in Mary Grace Wallis, FH-Prof. Dr. Paul Watson

2 SWS
3 ECTS

Lecture contents

The timetable for this semester will be provided as detailed information sheets and will be discussed during the first lesson.

The students will work on a projekt which they will present at the end of semester at a "workshop".

See also below (Objective of the course).

Assessment methods

Your command of English, both spoken and written, will be continuously assessed during the semester and will be reflected in the final semester mark. Moreover your active participation in the lessons will also contribute to the overall mark.

Teaching methods

Spontaneous and prepared presentations. Brainstormings, Discussions, Debates. ‘Language clinics’. Individual, pair- and group-work.

Language

English

2 3
Intellectual Property & Patent Law VO

Intellectual Property & Patent Law VO

Lector: Dr. Irene Fialka, CMC, Mag. Dr. Manuela Loidl

1 SWS
1 ECTS

Lecture contents

• Which forms of protection of intellectual property are available? – trademark, industrial design, copyright, utility model, complementary protection certificate, patent
• invention vs. innovation?
• history of patent rights
• Why patent protection?
• Patent?
– effects of a patent
– what can be patented and what ist excluded from patent protection?
– what are the prerequisites for patent application/protection?
– How to define inventor?
– rigths and obligaitons of inventors as employees
• From application to patent grant
– structure of a patent application
– application and granting processes
- protective reach and duration
– legal measures
– fees and costs
– Where to apply for a patent
• how to protect on an international level and important national differences
• Rights of patent owners and legal measures
• international agreements (EU, PCT)
• Biopatents – legal framework
• Freedom to Operate - what does it mean, what for?
• Espacenet and how to use it for patent research
• patent lawyer - the profession
• basics in copyright
• basics in industrial design
• basics in trademark
• strategies and decision making
• important agreements– MTAs, CDAs, licensing contracts
• Licensing contracts
– basic principles
– important clauses
– Franchise

Assessment methods

written exam at the end of the course
maximum number of points: 33
<16,5 (i.e. < 51%) insufficient
16,5 - 21 (i.e. 51% bis < 64%) sufficient
21,5 – 25 (i.e. 64% bis < 77%) satisfactory
25,5 – 30 (i.e. 77% bis < 91%) good
30,5-33 (i.e. ab 91%) excellent

Teaching methods

Lecture (with interactive elements)

1 1
Molecular Pathology LAB

Molecular Pathology LAB

Lector: Paula Dlugosz, MSc, Magdalena Fritz, BSc, Elisa Holstein, BSc, Ao. Univ. Prof. Mag. Dr. Wolfgang Mikulits, Ao. Univ. Prof. Mag. Dr. Ernst Müllner, Ao. Univ. Prof. Dr. DI Johannes Nimpf

4 SWS
5 ECTS

Lecture contents

Nimpf
Isolation and cultivation of chicken granulosa cells from large pre-ovulatory follicles
H&E staining of paraffin-sections of chicken follicles
Stimulation of fibroblasts expressing either ApoER2 and Dab1 or VLDLR and Dab1 with Reelin and subsequent detection of Dab1 phosphorylation by immunoprecipitation

Mikulits
Proliferation kinetics / clonogenic assay
Cell migration / wound healing assay
Cell migration / transwell assay

Müllner
H&E staining and documentation of paraffin-sections of human tumor samples
Human blood mononuclear cells: preparation, assessment, and flow cytometry

Assessment methods

Continuous assessment, quality of data analysis and content drafting of the lab report

Teaching methods

practical work in small groups under the supervision and guidance of lecturers and tutors;
Written and Web-based documents

Language

English

4 5
Molecular Pathology VO

Molecular Pathology VO

Lector: Ao. Univ. Prof. Mag. Dr. Wolfgang Mikulits, Ao. Univ. Prof. Mag. Dr. Ernst Müllner, Ao. Univ. Prof. Dr. DI Johannes Nimpf

2 SWS
3 ECTS

Lecture contents

I: culture of primary cells, organoids, cell engineering, tissue printing
II: hematopoiesis, hematopoietic stem cells, leukemia, leukemia treatment
III: stem cell transplantation, leukemia stem cells

Assessment methods

written exam at the end of the lecture

Teaching methods

classical lecture with material prepared by the lecturer

Language

German-English

2 3
Stem Cells LAB

Stem Cells LAB

Lector: Mag. Dr. Thomas Dechat, Nina Malajner, MSc, Dr. Arabella Meixner

3 SWS
3 ECTS

Lecture contents

The aim of this practical course is the experimental work with embryonic stem cells and induced stem cells. Culture conditions, charcaterization assays and embryoid body formation will be established. Gene expression analyses will be perforemd by RT-Rand qPCR.

Assessment methods

The grade combines: attendance, motivation, enthusiasm, written report

Teaching methods

Pratical course

3 3
Stem Cells VO

Stem Cells VO

Lector: Dr. Arabella Meixner

1 SWS
1 ECTS

Lecture contents

Stem cells have a great potential for organ regeneration. Why are stem cells so special? Which type of stem cells can be used? What kind of potential, how can cells be manipulated and how about the latest news in stem cell research will be discussed.

Assessment methods

Written examination

Teaching methods

Lectures with power point presentation

Language

English

1 1
Strategic Business Management 1 VO

Strategic Business Management 1 VO

Lector: DI Franz Gatterer, MBA

1 SWS
1 ECTS

Lecture contents

Strategic Management;
from vision to strategy;
Market analysis using Porter-Model;
SWOT as a useful tool to develop strategic options;
Product portfolio management (BCG-Model)

Assessment methods

Each student: written paper on this topic (approx. 2 Pages) will be evaluated. Topics/tasks will be worked on together with the students.

Teaching methods

Lectures with discussions, small peer-exercises

1 1

Vertiefungsrichtung Drug Discovery

Lecture SWS ECTS
Drug Screening LAB

Drug Screening LAB

Lector: FH-Prof. Dr. Thomas Czerny, Dr.in Elisabeth Riegel, Andrea Steinbauer, BSc MSc

3 SWS
4 ECTS

Lecture contents

The therapeutic potential of a small molecule drug will be estimated with a variety of cell based test systems. On the one hand the activating potential of the small molecule on a specific pathway (heat shock response pathway) is analysed and on the other hand possible cytotoxic effects are estimated in a concentration dependent manner. A broad variety of assays is provided for the students including luciferase reporter assays, Western blot, qPCR, flow cytometry, ELISA and general viability assays. The students themselves select suitable methods.

Assessment methods

consist of
pretest on experiment instructions
performance in the lab
protocols of the experiments
discussion of results after the course

Teaching methods

practical course with independent performance of the experiments

Language

English

3 4
Drug Screening VO

Drug Screening VO

Lector: Prof.(FH) Mag. Dr. Christoph Wiesner

1 SWS
2 ECTS

Lecture contents

Students will learn how to isolate natural drugs (small molecules) from plants or how to produce biologics. Course Content also includes different in vitro Screening methods, HCS, HTS (including target-and phenotype-based drug discovery).

Assessment methods

written exam 100%

Teaching methods

-

Language

English

1 2
Signalling Pathways LAB

Signalling Pathways LAB

Lector: FH-Prof. Dr. Thomas Czerny, Dr.in Elisabeth Riegel, Andrea Steinbauer, BSc MSc

3 SWS
3 ECTS

Lecture contents

Important methods for the analysis of signalling pathways are applied. In parallel the knowledge about specific pathways is broadened. Applied methods are transient transfection in cell culture, reporter constructs with gfp and luciferase, overexpression of activators/repressors, Western analysis of cellular extracts, in vitro phosphorylation, fluorescence microscopy of labelled proteins, analysis of the cytoskeleton, determination of translational activity and pharmacologic manipulation of the pathways.

Assessment methods

consist of
pretest on experiment instructions
performance in the lab
protocols of the experiments
discussion of results after the course

Teaching methods

combined with the lecture "Signalling Pathways"
lab work

Language

English

3 3
Signalling Pathways VO

Signalling Pathways VO

Lector: FH-Prof. Dr. Thomas Czerny

1 SWS
2 ECTS

Lecture contents

Important signalling pathways of the cell (e.g. MAP kinase-, GPCR-, Nuclear Hormone Receptor-, NF-kB-, Jak/Stat-, Wnt-, Hedgehog-, Tgfß-, Apoptosis-, PI3K/Akt- and stress pathways) are presented together with their effects on gene regulation and other functions of the cell. In addition the crosslinks with other pathways are discussed. Techniques for the analysis of signalling pathways are also presented, preparing the students for the practical course, which runs in parallel to the lecture.

Assessment methods

written exam

Teaching methods

lectures
Powerpoint presentations and down-loads
some chapters are discussed

Language

English

1 2
Therapeutic Strategies VO

Therapeutic Strategies VO

Lector: Doz. Mag. Dr. Wolfgang Sommergruber

1 SWS
2 ECTS

Lecture contents

Clinical failures and validity of targets, Extracellular signaling (endocrine – paracrine – autocrine; multitype); Mechanisms of signal transduction and the determination of the fate of a cell; Intracellular signal-transduction (signaling by phosphorylation and GTP-binding); PD-1/PD-L1 and CTLA-4 signaling in immune cells; Molecular mechanisms of EMT; Ligand-binding and effector specificity of receptor proteins; Acetylcholin: Same signal can lead to different effects in cells of different tissues;
Hormones: Small lipophilic molecules and their intracellular receptors; hydrophilic and lipophilic hormones and their cell-surface receptors; Hormone receptors (retinoid-x-receptor; PR, GR, AR and ER receptors); Hashimoto's thyroiditis, Graves' disease; nuclear receptors; Prostaglandin (PG) Biosynthesis (COX1, 2; COX inhibitors); prostaglandin signal-transduction pathways; Insect and snake venom (PLA2); Prostaglandins in breast cancer and endometriosis (autocrine and paracrine actions of PEG2 and PEF2a; biphasic activation of FGF-9 by PGE2; phagocytic ability of macrophages and PEG2; StAR and aromatase; aromatase inhibitors); G protein-coupled receptors; Ion-channel receptors; Tyrosine kinase-linked receptors; Receptors with intrinsic enzymatic activity; EGFR (mechanisms of EGFR dysregulation; therapeutic concepts, types of biomarkers); Molecular mechanisms of oncogene addiction and clinical resistance; Compensatory pathways in oncogenic kinase signaling and resistance to targeted therapies (EGFR, BRAF, SMO); Dual-specificity phosphatases: Critical regulators with diverse cellular targets; The hedgehog pathway in development and disease; Fusion proteins of ALK and their contribution to tumorigenesis; Tyrosine kinase-linked receptors; Types/mechanisms to die: Immunogenic cell death (ICD);

Assessment methods

Written exam
short oral presentation (FlipChart + feedback discussion)

Teaching methods

Oral presentations with PowerPoint slides
Printed handouts will be provided
Short presentations by students on selected topics (FlipChart)

Language

English

1 2

Vertiefungsrichtung Immunology

Lecture SWS ECTS
Immunology LAB

Immunology LAB

Lector: Andrea Steinbauer, BSc MSc, FH-Prof.in Univ.Doz.in Dr.in Ines Swoboda

3 SWS
3 ECTS

Lecture contents

In the laboratory the students will deepen their theoretical, immunological knowledge with examples from the field of Allergy. Students learn important immunological methods (ELISA, Western blot, immuno screening of cDNA libraries, isolation of human leukocytes, flow cytometry, cell activation test) and learn how these methods can be used for the isolation and immunological characterization of allergens.

Assessment methods

Active participation, protocol

Teaching methods

Practical course

Language

English

3 3
Immunology VO

Immunology VO

Lector: Univ.Prof. Mag. Dr. Wilfried Ellmeier, Univ.Doz. Ao. Univ.Prof. Dr. Herbert Strobl

2 SWS
3 ECTS

Lecture contents

The lecture aims to provide an overview about the interaction of the different immune cell subsets under physiological (e.g. during the course of an infection) and under pathophysiological conditions (e.g. immune-mediated diseases such as allergy and autoimmune diseases). In addition, we will discuss concepts of clinical immunology and diagnostic tools and applications.

Content discussed by Ellmeier:
1) Immediate Hypersensitivity - IgE-dependent immune responses and allergic diseases
2) Hypersensitivity disorders
3) Immunological tolerance and autoimmunity
4) Transplantation immunology
5) Regional immunity - gastrointestinal immune system and the microbiome
6) Therapeutic approaches to treat immune-mediated diseases

Assessment methods

written exam at the end of the lecture (mixture of multiple choice questions and "open" questions)

Teaching methods

Lecture

Language

English

2 3
Microbiology LAB

Microbiology LAB

Lector: Univ.Doz. Dr. Hans-Jürgen Busse, Andrea Steinbauer, BSc MSc

3 SWS
3 ECTS

Lecture contents

This course will introduce the students to the handling of bacteria and to demonstrate their diversity. In one experiment the dependence of chemo-physical conditions on the success of cultivation of bacteria will be studied and the results will be evaluated. In another experiment bacterial isolates from different human sources will be characterized morphologically and physiologically according to techniques often applied in clinical diagnostics. Furthermore it will be attempted to identify an antibiotic-producing bacterial isolate from soil. Finally, an examination of potable water for the bacterial load will be carried out in dependence to legal regulations

Assessment methods

Main criterion is the quality of the protocol but participation during the course may contribute, as well

Teaching methods

Learning by doing and observation

3 3
Molecular Virology VO

Molecular Virology VO

Lector: Ao.Univ.Prof. Dr. Dieter Klein, Dr.rer.nat. Christoph Metzner

1 SWS
1 ECTS

Lecture contents

The course covers the different phases of the viral lifecycle. Additionally, recent publications will be discussed during the course. Following subjects will be presented:
History and impact of viruses
Overview of the different viral life cycles
Viral entry and receptors
Viral replication
Assembly and budding
Viral maturation

Assessment methods

Written examination

Teaching methods

Lecture with discussions

Language

English

1 1
Pathology of Microbes VO

Pathology of Microbes VO

Lector: Univ. Prof. Dr. Franz Allerberger, Univ.Doz. Dr. Hans-Jürgen Busse, Priv. Doz. Dr. Irina Druzhinina, Priv. Doz. Dr. rer. nat. habil. Holger Scholz, FH-Prof.in Univ.Doz.in Dr.in Ines Swoboda

2 SWS
3 ECTS

Lecture contents

The students get to know the most important human pathogenic bacteria, fungi and parasites. The organizing principles are presented, which are used to investigate the relationship between microorganisms, and the resulting taxonomy will be explained. Furthermore, methods and techniques are presented, which are currently used for the diagnosis of microbes, with a special focus on the molecular diagnostics and molecular typing of highly pathogenic bacterial pathogens.

Assessment methods

Multiple Choice Test

Teaching methods

Lectures

Language

English

2 3

Lecture SWS ECTS
Bioethics VO

Bioethics VO

Lector: Dr.in Mary Grace Wallis

1 SWS
1 ECTS

Lecture contents

In seminar lectures the students have prepared in groups, they should present the ethical aspects and their pros and cons relevant to a selected topic. In plenary discussions these ethical aspects are deepened.

Assessment methods

Evaluation of oral presentation und resulting discussion

Teaching methods

Seminar lectures by students, discussion

Language

English

1 1
Biotech Seminar SE

Biotech Seminar SE

Lector: FH-Prof. Dr. Thomas Czerny, Dr.in Elisabeth Riegel

1 SWS
1 ECTS

Lecture contents

In this course the students learn strategies of scientific research. In a small group they develop such a strategy, by designing experiments and work packages which they evaluate according to different criteria like costs, effort, efficiency, .. Finally each group presents its strategy.

Assessment methods

Presentation und discussion of the developed strategy

Teaching methods

Seminar

Language

English

1 1
Clinical Development of Medicines VO

Clinical Development of Medicines VO

Lector: Prof. Dr. Bernhard Fischer, MBA

1 SWS
1 ECTS

Lecture contents

Overview of the clinical development process of biotechnology-derived molecules and drugs in the Eurpean Community. In addition to planning and performance of general clinical studies, special information for SME-organisations, for Orphan Drug Designation, for Advanced Therapy Products and for "high-risk" drugs will be provided.
Overview of the preclinical and clinical development process of biotechnology-derived molecules and drugs.

Assessment methods

Written examination at the end of the course.

Teaching methods

Lecture

Language

English

1 1
Forward and Reverse Genetics LAB

Forward and Reverse Genetics LAB

Lector: Dr.in Elisabeth Riegel, Andrea Steinbauer, BSc MSc

3 SWS
3 ECTS

Lecture contents

Experiments will be performed for genetic manipulation of living organisms and cell culture cells.
The program includes
Basics of the fish model system
microinjection of embryos
in situ hybridisation of embryos
use of transgenic lines with inducible expression
miRNA as a reverse genetics method

Assessment methods

Assessment of the work in the lab, written exams at the beginning and end of the lab course and a written summary of the experiments.

Teaching methods

lab work

Language

English

3 3
Gene Therapy Practical LAB

Gene Therapy Practical LAB

Lector: Reinhard Ertl, MSc, Ao.Univ.Prof. Dr. Dieter Klein, Dipl.Biol. Sarah Schlosser, Mag.rer.nat. Melanie Stargardt

3 SWS
3 ECTS

Lecture contents

The theoretical part of the lecture will introduce the basic aspects of gene transfers using retroviral vectors. Additionally, different methods for the estimation of the succes of gene transfer will be discussed in detail.
During the practical part of the course gene transfer experiments will be performed by the students. Afterwards the sucess of the gene transfer will be estimated using different molecular methods (FACS-analysis, real-time PCR, fluorescence mocroscopy).

Assessment methods

Assessment of the attendence and the written protocol

Teaching methods

Practical course including a theoretical part

Language

English

3 3
Gene Therapy VO

Gene Therapy VO

Lector: Ao.Univ.Prof. Dr. Dieter Klein, Dr.rer.nat. Christoph Metzner

1 SWS
1 ECTS

Lecture contents

The following topics will be covered during the course:
Principles of gene therapy
Overview on applications of gene therapy
Gene transfer methods
Methods for gene tranfer estimation
Characteristics of different viral vector systems
Non-viral vector systems
Retroviral vectors
Adenoviral vectors
Adeno-assoziated viral vectors
Other viral vectors
Applications of gene therapy for different diseases
Problems and perspectives

Assessment methods

Written Examination at the end of the lecture

Teaching methods

Lecture

Language

English

1 1
Proteomics LAB

Proteomics LAB

Lector: Claudia Ctortecka, MSc, DI Dr. Johannes Stadlmann

2 SWS
3 ECTS

Lecture contents

The lecture provides an introduction into the basic principles of proteomics: sample preparation & fractionation (1D and 2D GE, HPLC, CE, SCX RP and affinity chromatography, difficulty of contamination e.g. keratins, SDS, salts). Explanation of the principles of mass spectrometry: ion sources (MALDI, ESI), types of mass spectrometers (TOF, quadrupole, ion trap, FT ICR) and the respective combinations e.g. MALDI-TOF/TOF etc. Resultion R and mass accuracy dm/m (ppm). Improvement of the latter by delayed extraction & reflectron for MALDI-TOF. Isotopic distribution, single and multiple charged ions (ESI). PMF (peptide mass fingerprinting), principles of data base analysis of mass spectra. Collision induced dissociation CID, MS/MS analysis and de novo sequencing. In addition an introduction into the methods of quantitative proteomics, as well as the analysis of post-translational modifications.

During the "hands on" lab every student excises a band containg a protein out of a 4-20% SDS-PAGE (Tris/Glycin) gradient gel. Purification, reduction and alkylation of Cysteines, o/n digestion with Trypsin, next day spotting onto a MALDI target, and generation of a PMF mass spectrum with MALDI-TOF and MSMS spectra of the most intense peptides. Subsequently identification of the protein with database search algorithms.

Assessment methods

Lab work, lab protocol and written exam.

Teaching methods

Lecture, "hands on" lab work, computer lab to learn how to operate commonly used proteomics software (Mascot, Protein Prospector).

Language

English

2 3
Regulation of Gene Expression VO

Regulation of Gene Expression VO

Lector: FH-Prof. Dr. Thomas Czerny

1 SWS
2 ECTS

Lecture contents

The different levels of regulation of gene expression are discussed
Transcriptional regulation (transcription in eukaryotes, transcriptional activation, properties of transcription factors)
Posttranscriptional regulation (splicing, transport, stability of mRNA, translational control)
Effects of chromatin (composition, histone modifications, regulation, epigenetics)
Examples from signalling pathways

Assessment methods

written exam in the last lecture

Teaching methods

lectures
Powerpoint presentations and down-loads

Language

English

1 2
Scientific Method SE

Scientific Method SE

Lector: FH-Prof. Dr. Paul Watson

1 SWS
1 ECTS

Lecture contents

During this seminar, the students will present the topics of their Master thesis projects and discuss the chosen strategies and methods.

Assessment methods

continuous evaluation

Teaching methods

Presentations; Q & A sessions; independent literature searches.

Language

English

1 1
Strategic Business Management 2 ILV

Strategic Business Management 2 ILV

Lector: DI Franz Gatterer, MBA

2 SWS
2 ECTS

Lecture contents

Capstone Session on Business Management Context:

Alignment of the triangle:
* Strategic Perspective as Business Driver
* derived perspective on implementation through processes
* embedded perspective on humans through leadership session

create landscape of relevant knowledge in the sense of LL

special sessions from guest lecturer on business development and recruiting ..

Assessment methods

Evaluation of individual contributions and participation in given classroom discussions and Tasks.

Teaching methods

workshop, interactive conversations in groups, peers,

Language

English

2 2
Transcriptome LAB

Transcriptome LAB

Lector: Dr.in Anja Friedrich, Mag. Dr. Walter Glaser

2 SWS
3 ECTS

Lecture contents

1) Acquire knowledge on selected bioinformatics chapters (Next Generation Sequencing, ChIP-Seq, RNA-Seq) and
2) Application of relevant bioinformatics tools for the analysis of associated data

Assessment methods

100 % Protocol in which you have to analyse RNA-Seq Data/ ChIP-Seq Data

Teaching methods

- Introductions and explanations (lecture)
- Exercises using the computer

Language

English

2 3

Vertiefungsrichtung Drug Discovery

Lecture SWS ECTS
Biologicals VO

Biologicals VO

Lector: Dr. Christian Kössl

1 SWS
1 ECTS

Lecture contents

The lecture “Biologicals” gives an overview over the most important aspects of biotherapeutics (=biologics) which is the fastest growing type of drug gaining more and more importance.
Focus of the lecture are the discovery research of therapeutic concepts enabled by engineering of biologics, bioprocess development of biologicals, and manufacturing aspects.

Major differences and therapeutic aspects differing between small molecule drugs and biologics are discussed; examples of major classes of biologics will be presented as case studies.

Discovery and engineering of therapeutic monoclonal antibodies will be discussed in more detail as this class of therapeutics reflects the biggest class amongst many other biologicals.
Approaches and technologies for biopharmaceutical manufacturing and purification will be discussed; major aspects and challenges of protein analytics and physicochemical characterization of biologics will be highlighted.

Assessment methods

written exam in the last lecture

Teaching methods

lecture

Language

English

1 1
Drug Target Interactions VO

Drug Target Interactions VO

Lector: Dr. Klaus Rumpel

2 SWS
2 ECTS

Lecture contents

At the center of this course is the drug and its interaction with target proteins. Methods for determination of protein structures and characterization and quantification of protein ligand interactions are presented. In addition strategies and methods for the optimization of these interactions are discussed (lead optimization, rational design). Furthermore, aspects of pharmacokinetics (ADME, prodrugs) are presented. The underlying principles are demonstrated by selected examples.

Assessment methods

written exam in the last lecture

Teaching methods

lectures
Powerpoint presentations and down-loads

Language

English

2 2
Laboratory Animals LAB

Laboratory Animals LAB

Lector: Ao.-Prof. DI Dr. Thomas Kolbe, Univ. Prof. Dr. Thomas Rülicke, Mag. med. vet. Gabriele Schöppl, Dr.med.vet Christiana Winding-Zavadil

1 SWS
1 ECTS

Lecture contents

The aim of the lecture is to gain skills and expertise in laboratory animal handling and behavior (with a focus on mouse and rat) and acquisition of techniques for substance application and sampling.
Practical training for personnel carrying out procedures on animals according to FELASA B guidelines.

Assessment methods

participation and written examination

Teaching methods

Demonstration and tutorial

Language

English

1 1
Laboratory Animals VO

Laboratory Animals VO

Lector: Univ. Prof. Dr. Thomas Rülicke

2 SWS
2 ECTS

Lecture contents

The development and current topics of Laboratory animal science as a discipline in biomedical sciences. Laboratory rodent husbandry, hygienic concepts and their monitoring. The principles of the three R’s during planning and implementation of animal experiments.

Assessment methods

written examination

Teaching methods

presentation

Language

English

2 2
Molecular Pharmacology VO

Molecular Pharmacology VO

Lector: Mag. Dr. Gerda Brunhofer-Bolzer

2 SWS
3 ECTS

Lecture contents

Structure and function of drug targets on the molecular level as well as their role as regulators of cell function, the prodrug strategy, most frequently prescribed drugs for the treatment of human diseases (e.g. background of a disease, mechanism of action, important side effects)

Assessment methods

Written examination at the end of the course, evaluation of the tasks provided during the course

Teaching methods

Each topic is introduced and necessary information is provided through didactic lectures and e-learning methods. Subsequent lectures focus on the use of this information (e.g. discussion of research papers or research problems, student/poster presentations).

Language

English

2 3

Vertiefungsrichtung Immunology

Lecture SWS ECTS
Neurobiology VO

Neurobiology VO

Lector: Dr.phil. Dr. med.univ. Karl-Heinz Huemer

2 SWS
3 ECTS

Lecture contents

membrane physiology, action potentials, elektrotonic/saltatoric conduction, synapses, important transmitter systems & pharmacological modulation, temporal & spatial integration, pre/postsynaptic inhibition
motor functions of the spinal chord, basal ganglia, cerebellum and cortex incl changes of lesions in these regions
structure and function of the autonomic nervous system (peripheral & central coordination) incl effects on important organs
sensory systems: mechanorecption, pain, equilibrium, smell, taste
CNS: cortex, EEG, activationg systems, sleep, circadian rhythms, learning & memory, language

Assessment methods

written exam

Teaching methods

lecture

Language

English

2 3
Vaccine Development SE

Vaccine Development SE

Lector: FH-Prof.in Univ.Doz.in Dr.in Ines Swoboda

1 SWS
1 ECTS

Lecture contents

The seminar deepens the students' knowledge in the field of vaccine development by operating first in-depth literature search on selected topics and then summarizing the knowledge acquired in a presentation and in a written work.
Students will actively participate in the presentations of other colleagues, in which they ask questions and offer constructive criticism.

Assessment methods

Presentation, discussion, manuscript

Teaching methods

Seminar (literature search, presentation, discussion, manuscript)

Language

English

1 1
Vaccine Development VO

Vaccine Development VO

Lector: Dr. Shailesh Dewasthaly

1 SWS
2 ECTS

Lecture contents

The course will begin with general product development in the field of pharmaceutical world. From product development, intricacies involving vaccine product development will be discussed. Detailed discussions on some approved/licensed vaccines will also be done. Some important aspects of vaccine production cGMP will also be a part of the lecture. Since most of the above discussions will be from an 'industry perspective' one lecture will be held to describe the 'regulatory authority perspective'.

Assessment methods

Seminar assignment and presentation

Teaching methods

Normal interactive lectures with power point slides.

Language

English

1 2
Vascular Biology VO

Vascular Biology VO

Lector: Julia Pointner, PhD, Assoc. Prof. Priv.-Doz. Dr. Gernot Schabbauer

2 SWS
3 ECTS

Lecture contents

The present lecture is sectioned in two major topics: hematology and vascular biology/pathology.

HEMATOLOGY

1. erythrocytes: structure, cytoskeleton, hemoglobin, gas-exchange, degradation of erythrocytes, iron metabolism, blood types.
2. leukocytes: morphological leukocyte determination in light microscopy
3. thrombocytes: structure, activation, adhesion, aggregation, interaction with cells or ECM
4. hemostasis: coagulation, cell-based model of hemostasis, fibrinolysis, inhibitors, coagulations tests
5. laboratory diagnostics: sample preparation, plasma/serum, clinical chemistry, red/white blood cell counts, serology
6. hematological disorders: reactive disorders of erythrocytes/leukocytes/thrombocytes, malfunction of hemostasis

VASCULAR BIOLOGY
1. overview of the vascular system: definitions, structure, blood/lymph-system
2. development of blood vessels: vasculogenesis, angiogenesis, role of specific angiogenic growth factors
3. the endothelium: biology of endothelial cells, structure of endothelium, types of endothelium
4. features of the endothelium: regulation of vascular tone, endothelium and cell adhesion, endothelial dysfunction

VASCULAR PATHOLOGY
1. the role of the endothelium in acute inflammatory response: systemic and local disease - e.g. sepsis and acute lung injury
2. atherosclerosis as a chronic inflammatory process: risk factors, lipid metabolism, atherogenesis, pathophysiology of instable lesions/plaque rupture, animal models of atherosclerosis research

Assessment methods

The written exam consists of 40 single choice questions and 3 general questions (one for each topic of the lecture). Grades are based on the average score of participants.

Teaching methods

Lecture (Power-Point presentations, board), recent reviews.

Language

English

2 3

Lecture SWS ECTS
Master Seminar SE

Master Seminar SE

Lector: FH-Prof. Dr. Paul Watson

2 SWS
2 ECTS

Lecture contents

In the Master thesis seminar, students present the topic of their thesis projectand give a status report on their progress. They will also actively participate in the presentations of other speakers (asking questions, constructive criticism, etc.).

Assessment methods

Active participation

Teaching methods

-

Language

German-English

2 2
Master Thesis VO

Master Thesis VO

Lector: FH-Prof. Dr. Herbert Wank, FH-Prof. Dr. Paul Watson

0 SWS
28 ECTS

Lecture contents

Undertaking independent research on a scientific topic and then writing a Master thesis.

Assessment methods

Expert assessment

Teaching methods

Research

Language

German-English

0 28