Current Curriculum Molecular Biotechnology

Lecture SWS ECTS
English: The Language of Science ILV 2 2
Entrepreneurship and Start-ups ILV 2 2
General Pathology VO 2 3
Genetic Testing LAB 2 2
Genetic Testing Seminar SE 1 1
Genetic Testing VO 2 3
In Silico Biology LAB 3 3
In Silico Biology VO 1 2
Infection Biology VO 1 2
Innovation/Knowledge/Technology VO 1 1
Intercultural Teams in Interdisciplinary Projects ILV 1 1
RNA Lab LAB 3 3
RNA VO 1 2
Tumour Biology VO 2 3

Lecture SWS ECTS
English: The Language of Science ILV 2 3
Intellectual Property & Patent Law VO 1 1
Molecular Pathology LAB 4 5
Molecular Pathology VO 2 3
Stem Cells LAB 3 3
Stem Cells VO 1 1
Strategic Business Management 1 VO 1 1

Vertiefungsrichtung Drug Discovery

Lecture SWS ECTS
Drug Screening LAB 3 4
Drug Screening VO 1 2
Signalling Pathways LAB 3 3
Signalling Pathways VO 1 2
Therapeutic Strategies VO 1 2

Vertiefungsrichtung Immunology

Lecture SWS ECTS
Immunology LAB 3 3
Immunology VO 2 3
Microbiology LAB 3 3
Molecular Virology VO 1 1
Pathology of Microbes VO 2 3

Lecture SWS ECTS
Bioethics VO

Bioethics VO

Lector: Dr.in Mary Grace Wallis

1 SWS
1 ECTS

Lecture contents

In seminar lectures the students have prepared in groups, they should present the ethical aspects and their pros and cons relevant to a selected topic. In plenary discussions these ethical aspects are deepened.

Assessment methods

Evaluation of oral presentation und resulting discussion

Teaching methods

Seminar lectures by students, discussion

Language

English

1 1
Biotech Seminar SE

Biotech Seminar SE

Lector: FH-Prof. Dr. Thomas Czerny, Dr.in Elisabeth Riegel

1 SWS
1 ECTS

Lecture contents

In this course the students learn strategies of scientific research. In a small group they develop such a strategy, by designing experiments and work packages which they evaluate according to different criteria like costs, effort, efficiency, .. Finally each group presents its strategy.

Assessment methods

Presentation und discussion of the developed strategy

Teaching methods

Seminar

Language

English

1 1
Clinical Development of Medicines VO

Clinical Development of Medicines VO

Lector: Prof. Dr. Bernhard Fischer, MBA

1 SWS
1 ECTS

Lecture contents

Overview of the clinical development process of biotechnology-derived molecules and drugs in the Eurpean Community. In addition to planning and performance of general clinical studies, special information for SME-organisations, for Orphan Drug Designation, for Advanced Therapy Products and for "high-risk" drugs will be provided.
Overview of the preclinical and clinical development process of biotechnology-derived molecules and drugs.

Assessment methods

Written examination at the end of the course.

Teaching methods

Lecture

Language

English

1 1
Forward and Reverse Genetics LAB

Forward and Reverse Genetics LAB

Lector: Dr.in Elisabeth Riegel, Andrea Steinbauer, BSc MSc

3 SWS
3 ECTS

Lecture contents

Experiments will be performed for genetic manipulation of living organisms and cell culture cells.
The program includes
Basics of the fish model system
microinjection of embryos
in situ hybridisation of embryos
use of transgenic lines with inducible expression
miRNA as a reverse genetics method

Assessment methods

Assessment of the work in the lab, written exams at the beginning and end of the lab course and a written summary of the experiments.

Teaching methods

lab work

Language

English

3 3
Gene Therapy Practical LAB

Gene Therapy Practical LAB

Lector: Reinhard Ertl, MSc, Ao.Univ.Prof. Dr. Dieter Klein, Mag.rer.nat. Melanie Korb, Dipl.Biol. Sarah Schlosser

3 SWS
3 ECTS

Lecture contents

The theoretical part of the lecture will introduce the basic aspects of gene transfers using retroviral vectors. Additionally, different methods for the estimation of the succes of gene transfer will be discussed in detail.
During the practical part of the course gene transfer experiments will be performed by the students. Afterwards the sucess of the gene transfer will be estimated using different molecular methods (FACS-analysis, real-time PCR, fluorescence mocroscopy).

Assessment methods

Assessment of the attendence and the written protocol

Teaching methods

Practical course including a theoretical part

Language

English

3 3
Gene Therapy VO

Gene Therapy VO

Lector: Ao.Univ.Prof. Dr. Dieter Klein, Dr.rer.nat. Christoph Metzner

1 SWS
1 ECTS

Lecture contents

The following topics will be covered during the course:
Principles of gene therapy
Overview on applications of gene therapy
Gene transfer methods
Methods for gene tranfer estimation
Characteristics of different viral vector systems
Non-viral vector systems
Retroviral vectors
Adenoviral vectors
Adeno-assoziated viral vectors
Other viral vectors
Applications of gene therapy for different diseases
Problems and perspectives

Assessment methods

Written Examination at the end of the lecture

Teaching methods

Lecture

Language

English

1 1
Proteomics LAB

Proteomics LAB

2 SWS
3 ECTS

Lecture contents

The lecture provides an introduction into the basic principles of proteomics: sample preparation & fractionation (1D and 2D GE, HPLC, CE, SCX RP and affinity chromatography, difficulty of contamination e.g. keratins, SDS, salts). Explanation of the principles of mass spectrometry: ion sources (MALDI, ESI), types of mass spectrometers (TOF, quadrupole, ion trap, FT ICR) and the respective combinations e.g. MALDI-TOF/TOF etc. Resultion R and mass accuracy dm/m (ppm). Improvement of the latter by delayed extraction & reflectron for MALDI-TOF. Isotopic distribution, single and multiple charged ions (ESI). PMF (peptide mass fingerprinting), principles of data base analysis of mass spectra. Collision induced dissociation CID, MS/MS analysis and de novo sequencing. In addition an introduction into the methods of quantitative proteomics, as well as the analysis of post-translational modifications.

During the "hands on" lab every student excises a band containg a protein out of a 4-20% SDS-PAGE (Tris/Glycin) gradient gel. Purification, reduction and alkylation of Cysteines, o/n digestion with Trypsin, next day spotting onto a MALDI target, and generation of a PMF mass spectrum with MALDI-TOF and MSMS spectra of the most intense peptides. Subsequently identification of the protein with database search algorithms.

Assessment methods

Lab work, lab protocol and written exam.

Teaching methods

Lecture, "hands on" lab work, computer lab to learn how to operate commonly used proteomics software (Mascot, Protein Prospector).

Language

English

2 3
Regulation of Gene Expression VO

Regulation of Gene Expression VO

Lector: FH-Prof. Dr. Thomas Czerny

1 SWS
2 ECTS

Lecture contents

The different levels of regulation of gene expression are discussed
Transcriptional regulation (transcription in eukaryotes, transcriptional activation, properties of transcription factors)
Posttranscriptional regulation (splicing, transport, stability of mRNA, translational control)
Effects of chromatin (composition, histone modifications, regulation, epigenetics)
Examples from signalling pathways

Assessment methods

written exam in the last lecture

Teaching methods

lectures
Powerpoint presentations and down-loads

Language

English

1 2
Scientific Method SE

Scientific Method SE

Lector: FH-Prof. Dr. Paul Watson

1 SWS
1 ECTS

Lecture contents

During this seminar, the students will present the topics of their Master thesis projects and discuss the chosen strategies and methods.

Assessment methods

continuous evaluation

Teaching methods

Presentations; Q & A sessions; independent literature searches.

Language

English

1 1
Strategic Business Management 2 ILV

Strategic Business Management 2 ILV

Lector: DI Franz Gatterer, MBA

2 SWS
2 ECTS

Lecture contents

Capstone Session on Business Management Context:

Alignment of the triangle:
* Strategic Perspective as Business Driver
* derived perspective on implementation through processes
* embedded perspective on humans through leadership session

create landscape of relevant knowledge in the sense of LL

special sessions from guest lecturer on business development and recruiting ..

Assessment methods

Evaluation of individual contributions and participation in given classroom discussions and Tasks.

Teaching methods

workshop, interactive conversations in groups, peers,

Language

English

2 2
Transcriptome LAB

Transcriptome LAB

Lector: Dr.in Anja Friedrich, Mag. Dr. Walter Glaser

2 SWS
3 ECTS

Lecture contents

1) Acquire knowledge on selected bioinformatics chapters (Next Generation Sequencing, ChIP-Seq, RNA-Seq) and
2) Application of relevant bioinformatics tools for the analysis of associated data

Assessment methods

100 % Protocol in which you have to analyse RNA-Seq Data/ ChIP-Seq Data

Teaching methods

- Introductions and explanations (lecture)
- Exercises using the computer

Language

English

2 3

Vertiefungsrichtung Drug Discovery

Lecture SWS ECTS
Biologicals VO

Biologicals VO

Lector: Dr. Christian Kössl

1 SWS
1 ECTS

Lecture contents

The lecture “Biologicals” gives an overview over the most important aspects of biotherapeutics (=biologics) which is the fastest growing type of drug gaining more and more importance.
Focus of the lecture are the discovery research of therapeutic concepts enabled by engineering of biologics, bioprocess development of biologicals, and manufacturing aspects.

Major differences and therapeutic aspects differing between small molecule drugs and biologics are discussed; examples of major classes of biologics will be presented as case studies.

Discovery and engineering of therapeutic monoclonal antibodies will be discussed in more detail as this class of therapeutics reflects the biggest class amongst many other biologicals.
Approaches and technologies for biopharmaceutical manufacturing and purification will be discussed; major aspects and challenges of protein analytics and physicochemical characterization of biologics will be highlighted.

Assessment methods

written exam in the last lecture

Teaching methods

lecture

Language

English

1 1
Drug Target Interactions VO

Drug Target Interactions VO

Lector: Dr. Klaus Rumpel

2 SWS
2 ECTS

Lecture contents

At the center of this course is the drug and its interaction with target proteins. Methods for determination of protein structures and characterization and quantification of protein ligand interactions are presented. In addition strategies and methods for the optimization of these interactions are discussed (lead optimization, rational design). Furthermore, aspects of pharmacokinetics (ADME, prodrugs) are presented. The underlying principles are demonstrated by selected examples.

Assessment methods

written exam in the last lecture

Teaching methods

lectures
Powerpoint presentations and down-loads

Language

English

2 2
Laboratory Animals LAB

Laboratory Animals LAB

Lector: Ao.-Prof. DI Dr. Thomas Kolbe, Univ. Prof. Dr. Thomas Rülicke, Dr.med.vet Christiana Winding-Zavadil

1 SWS
1 ECTS

Lecture contents

The aim of the lecture is to gain skills and expertise in laboratory animal handling and behavior (with a focus on mouse and rat) and acquisition of techniques for substance application and sampling.
Practical training for personnel carrying out procedures on animals according to FELASA B guidelines.

Assessment methods

participation and written examination

Teaching methods

Demonstration and tutorial

Language

English

1 1
Laboratory Animals VO

Laboratory Animals VO

Lector: Univ. Prof. Dr. Thomas Rülicke

2 SWS
2 ECTS

Lecture contents

The development and current topics of Laboratory animal science as a discipline in biomedical sciences. Laboratory rodent husbandry, hygienic concepts and their monitoring. The principles of the three R’s during planning and implementation of animal experiments.

Assessment methods

written examination

Teaching methods

presentation

Language

English

2 2
Molecular Pharmacology VO

Molecular Pharmacology VO

Lector: Mag. Dr. Gerda Brunhofer-Bolzer

2 SWS
3 ECTS

Lecture contents

Structure and function of drug targets on the molecular level as well as their role as regulators of cell function, the prodrug strategy, most frequently prescribed drugs for the treatment of human diseases (e.g. background of a disease, mechanism of action, important side effects)

Assessment methods

Written examination at the end of the course, evaluation of the tasks provided during the course

Teaching methods

Each topic is introduced and necessary information is provided through didactic lectures and e-learning methods. Subsequent lectures focus on the use of this information (e.g. discussion of research papers or research problems, student/poster presentations).

Language

English

2 3

Vertiefungsrichtung Immunology

Lecture SWS ECTS
Neurobiology VO

Neurobiology VO

Lector: Dr.phil. Dr. med.univ. Karl-Heinz Huemer

2 SWS
3 ECTS

Lecture contents

membrane physiology, action potentials, elektrotonic/saltatoric conduction, synapses, important transmitter systems & pharmacological modulation, temporal & spatial integration, pre/postsynaptic inhibition
motor functions of the spinal chord, basal ganglia, cerebellum and cortex incl changes of lesions in these regions
structure and function of the autonomic nervous system (peripheral & central coordination) incl effects on important organs
sensory systems: mechanorecption, pain, equilibrium, smell, taste
CNS: cortex, EEG, activationg systems, sleep, circadian rhythms, learning & memory, language

Assessment methods

written exam

Teaching methods

lecture

Language

English

2 3
Vaccine Development SE

Vaccine Development SE

Lector: FH-Prof.in Univ.Doz.in Dr.in Ines Swoboda

1 SWS
1 ECTS

Lecture contents

The seminar deepens the students' knowledge in the field of vaccine development by operating first in-depth literature search on selected topics and then summarizing the knowledge acquired in a presentation and in a written work.
Students will actively participate in the presentations of other colleagues, in which they ask questions and offer constructive criticism.

Assessment methods

Presentation, discussion, manuscript

Teaching methods

Seminar (literature search, presentation, discussion, manuscript)

Language

English

1 1
Vaccine Development VO

Vaccine Development VO

Lector: Dr. Shailesh Dewasthaly

1 SWS
2 ECTS

Lecture contents

The course will begin with general product development in the field of pharmaceutical world. From product development, intricacies involving vaccine product development will be discussed. Detailed discussions on some approved/licensed vaccines will also be done. Some important aspects of vaccine production cGMP will also be a part of the lecture. Since most of the above discussions will be from an 'industry perspective' one lecture will be held to describe the 'regulatory authority perspective'.

Assessment methods

Seminar assignment and presentation

Teaching methods

Normal interactive lectures with power point slides.

Language

English

1 2
Vascular Biology VO

Vascular Biology VO

Lector: Julia Pointner, PhD, Assoc. Prof. Priv.-Doz. Dr. Gernot Schabbauer

2 SWS
3 ECTS

Lecture contents

The present lecture is sectioned in two major topics: hematology and vascular biology/pathology.

HEMATOLOGY

1. erythrocytes: structure, cytoskeleton, hemoglobin, gas-exchange, degradation of erythrocytes, iron metabolism, blood types.
2. leukocytes: morphological leukocyte determination in light microscopy
3. thrombocytes: structure, activation, adhesion, aggregation, interaction with cells or ECM
4. hemostasis: coagulation, cell-based model of hemostasis, fibrinolysis, inhibitors, coagulations tests
5. laboratory diagnostics: sample preparation, plasma/serum, clinical chemistry, red/white blood cell counts, serology
6. hematological disorders: reactive disorders of erythrocytes/leukocytes/thrombocytes, malfunction of hemostasis

VASCULAR BIOLOGY
1. overview of the vascular system: definitions, structure, blood/lymph-system
2. development of blood vessels: vasculogenesis, angiogenesis, role of specific angiogenic growth factors
3. the endothelium: biology of endothelial cells, structure of endothelium, types of endothelium
4. features of the endothelium: regulation of vascular tone, endothelium and cell adhesion, endothelial dysfunction

VASCULAR PATHOLOGY
1. the role of the endothelium in acute inflammatory response: systemic and local disease - e.g. sepsis and acute lung injury
2. atherosclerosis as a chronic inflammatory process: risk factors, lipid metabolism, atherogenesis, pathophysiology of instable lesions/plaque rupture, animal models of atherosclerosis research

Assessment methods

The written exam consists of 40 single choice questions and 3 general questions (one for each topic of the lecture). Grades are based on the average score of participants.

Teaching methods

Lecture (Power-Point presentations, board), recent reviews.

Language

English

2 3

Lecture SWS ECTS
Master Seminar SE

Master Seminar SE

2 SWS
2 ECTS

Lecture contents

In the Master thesis seminar, students present the topic of their thesis projectand give a status report on their progress. They will also actively participate in the presentations of other speakers (asking questions, constructive criticism, etc.).

Assessment methods

Active participation

Teaching methods

-

Language

German-English

2 2
Master Thesis VO

Master Thesis VO

Lector: FH-Prof. Dr. Herbert Wank, FH-Prof. Dr. Paul Watson

0 SWS
28 ECTS

Lecture contents

Undertaking independent research on a scientific topic and then writing a Master thesis.

Assessment methods

Expert assessment

Teaching methods

Research

Language

German-English

0 28