Details

FH-Prof. Dr. Thomas Czerny

Academic Staff
"Stadt Wien" Endowed Professorship for Cell-Based Test Systems


T: +43 1 606 68 77-3511
F: +43 1 606 68 77-3509

Room: OG.F.06
Helmut Qualtinger Gasse 2
1030 Wien


Lectures 2019/20

Applied Life Sciences

> Biologicals VO
Molecular Biotechnologymore

Biologicals VO

Lector: FH-Prof. Dr. Thomas Czerny

1 SWS
1 ECTS

Lecture contents

The lecture “Biologicals” gives an overview over the most important aspects of biotherapeutics (=biologics) which is the fastest growing type of drug gaining more and more importance.
Focus of the lecture are the discovery research of therapeutic concepts enabled by engineering of biologics, bioprocess development of biologicals, and manufacturing aspects.

Major differences and therapeutic aspects differing between small molecule drugs and biologics are discussed; examples of major classes of biologics will be presented as case studies.

Discovery and engineering of therapeutic monoclonal antibodies will be discussed in more detail as this class of therapeutics reflects the biggest class amongst many other biologicals.
Approaches and technologies for biopharmaceutical manufacturing and purification will be discussed; major aspects and challenges of protein analytics and physicochemical characterization of biologics will be highlighted.

Assessment methods

written exam in the last lecture

Teaching methods

lecture

Language

English

> Biotech Seminar SE
Molecular Biotechnologymore

Biotech Seminar SE

Lector: FH-Prof. Dr. Thomas Czerny, Dr.in Elisabeth Riegel

1 SWS
1 ECTS

Lecture contents

In this course the students learn strategies of scientific research. In a small group they develop such a strategy, by designing experiments and work packages which they evaluate according to different criteria like costs, effort, efficiency, .. Finally each group presents its strategy.

Assessment methods

Presentation und discussion of the developed strategy

Teaching methods

Seminar

Language

English

> Biotech Seminar SE
Molecular Biotechnologymore

Biotech Seminar SE

Lector: FH-Prof. Dr. Thomas Czerny

1 SWS
1 ECTS

Lecture contents

In this course the students learn strategies of scientific research. In a small group they develop such a strategy, by designing experiments and work packages which they evaluate according to different criteria like costs, effort, efficiency, .. Finally each group presents its strategy.

Assessment methods

Presentation und discussion of the developed strategy

Teaching methods

Seminar

Language

English

> Drug Discovery SE
Molecular Biotechnologymore

Drug Discovery SE

1 SWS
1 ECTS

Lecture contents

In this course research papers from internationally respected high-quality journals from the field of Drug Discovery are distributed to the students who read them on their own. The seminar itself then takes the format of a peer-group discussion, where students present the background, the most important findings and the conclusion of the publications. Furthermore, they discuss the strengths and the weaknesses of the publications and make suggestions for improvements.

Assessment methods

Seminar paper
Participation in discussion

Teaching methods

Seminar

Language

English

> Drug Target Interactions VO
Molecular Biotechnologymore

Drug Target Interactions VO

Lector: FH-Prof. Dr. Thomas Czerny, Dr. Klaus Rumpel

2 SWS
2 ECTS

Lecture contents

At the center of this course is the drug and its interaction with target proteins. Methods for determination of protein structures and characterization and quantification of protein ligand interactions are presented. In addition strategies and methods for the optimization of these interactions are discussed (lead optimization, rational design). Furthermore, aspects of pharmacokinetics (ADME, prodrugs) are presented. The underlying principles are demonstrated by selected examples.

Assessment methods

written exam in the last lecture

Teaching methods

lectures
Powerpoint presentations and down-loads

Language

English

> Forward and Reverse Genetics LAB
Molecular Biotechnologymore

Forward and Reverse Genetics LAB

Lector: FH-Prof. Dr. Thomas Czerny, Dr.in Elisabeth Riegel

3 SWS
3 ECTS

Lecture contents

Experiments will be performed for genetic manipulation of living organisms and cell culture cells.
The program includes
Basics of the fish model system
microinjection of embryos
in situ hybridisation of embryos
use of transgenic lines with inducible expression
miRNA as a reverse genetics method

Assessment methods

Assessment of the work in the lab, written exams at the beginning and end of the lab course and a written summary of the experiments.

Teaching methods

lab work

Language

English

> General Biology VO
Molecular Biotechnologymore

General Biology VO

Lector: FH-Prof. Dr. Thomas Czerny

2 SWS
3 ECTS

Lecture contents

Darwinian evolution, creationism and intelligent design. Driving forces and mechanisms of evolution, population genetics, phylogeny and formation of species. Physical and chemical basis of life and energy requirements. History of life on our planet and milestones of evolution: origin of life, oxygen, eukaryotes, sexual reproduction and multicellular organisms. Features of pro- and eukrayotic cells and the phylogeny of life. Kingdoms of life: eubacteria, archaea, protists, fungi, plants and animals. Human evolution and the scientific method.

Assessment methods

Tests during the semester, a written exam at the end of the lectures

Teaching methods

Oral presentations

> Genome Organization ILV
Molecular Biotechnologymore

Genome Organization ILV

Lector: FH-Prof. Dr. Thomas Czerny

1 SWS
2 ECTS
> Molecular Genetics VO
Molecular Biotechnologymore

Molecular Genetics VO

1.5 SWS
2 ECTS

Lecture contents

- Fundamental features of genetics and genetic engineering
- Different levels of regulation of gene expression in pro- and eukaryotes
- Transcriptional regulation (transcription in eukaryotes, transcriptional activation, properties of transcription factors)
- Posttranscriptional regulation (splicing, transport, stability of mRNA, translational control)
- Effects of chromatin (composition, histone modifications, regulation, epigenetics)
- Examples from signalling pathways

Assessment methods

Final exam
Written exams

Teaching methods

Lectures with Powerpoint presentations

Language

English

> Regulation of Gene Expression VO
Molecular Biotechnologymore

Regulation of Gene Expression VO

Lector: FH-Prof. Dr. Thomas Czerny

1 SWS
2 ECTS

Lecture contents

The different levels of regulation of gene expression are discussed
Transcriptional regulation (transcription in eukaryotes, transcriptional activation, properties of transcription factors)
Posttranscriptional regulation (splicing, transport, stability of mRNA, translational control)
Effects of chromatin (composition, histone modifications, regulation, epigenetics)
Examples from signalling pathways

Assessment methods

written exam in the last lecture

Teaching methods

lectures
Powerpoint presentations and down-loads

Language

English

> Regulation of Gene Expression VO
Molecular Biotechnologymore

Regulation of Gene Expression VO

Lector: FH-Prof. Dr. Thomas Czerny

1 SWS
2 ECTS

Lecture contents

The different levels of regulation of gene expression are discussed
Transcriptional regulation (transcription in eukaryotes, transcriptional activation, properties of transcription factors)
Posttranscriptional regulation (splicing, transport, stability of mRNA, translational control)
Effects of chromatin (composition, histone modifications, regulation, epigenetics)
Examples from signalling pathways

Assessment methods

written exam in the last lecture

Teaching methods

lectures
Powerpoint presentations and down-loads

Language

English

> Signalling Pathways VO
Molecular Biotechnologymore

Signalling Pathways VO

1 SWS
2 ECTS

Lecture contents

Important signalling pathways of the cell (e.g. MAP kinase-, GPCR-, Nuclear Hormone Receptor-, NF-kB-, Jak/Stat-, Wnt-, Hedgehog-, Tgfß-, Apoptosis-, PI3K/Akt- and stress pathways) are presented together with their effects on gene expression and other functions of the cell. In addition the crosslinks with other pathways are discussed. Techniques for the analysis of signalling pathways are also presented.

Assessment methods

Final exam
Written Exam

Teaching methods

Lectures with Powerpoint presentations, Discussion of selected chapters

Language

English

Publications

The publications of Thomas Czerny written at FH Campus Wien can be found in our publication database, others in the personal web space.