© FH Campus Wien FH-Prof. DI Dr. Michael Maurer Head of Degree Program Bioengineering, Bioinformatics, Biotechnological Quality Management, Bioprocess Engineering michael.maurer@fh-campuswien.ac.at T: +43 1 606 68 77-3601 F: +43 1 606 68 77-3609Room: Büro01 Muthgasse 62 1190 Wien Lectures 2019/20 Applied Life Sciences > Bioreactors and Bioprocess Engineering ILVBioprocess Technologymore Bioreactors and Bioprocess Engineering ILV Lector: Hon.-Prof. Univ.-Doz. DI Dr. Rudolf Friedrich Bliem, FH-Prof. DI Dr. Michael Maurer 2 SWS 4 ECTS Lecture contents After the introduction, where the basic concepts and principles of bioprocess engineering are explained, the main bioreactor types and operation modes are presented. In the following section the kinetics of bioprocesses together with the underlying equations and graphs are outlined. Heat and mass transfer correlations, which are essential to be familiar with - especially for the design of bioreactors, are dealt in the following section. The characterization of various bioreactor types including enzyme reactors as weell as the upscaling principles are main topics of this lecture. Finally the basics of the sterilization technology and the design of SIP procedures are elucidated.The understanding as well as the benefit of the presented model equations for the particular unit operations are shown by some selected examples. Assessment methods Two written intermediate exams and a final test. Teaching methods The teaching is based on the following concept:First the scientific principles involved in a specific unit operation within biochemical engineering together with their practical application are elucidated. After a thorough discussion on the limitations of the respective Mathematical Model its practical value is shown by some examples. > Biotechnological Seminar UEBioinformaticsmore Biotechnological Seminar UE Lector: FH-Prof.in Mag.a Dr.in Alexandra Graf, FH-Prof. DI Dr. Michael Maurer 0.5 SWS 1 ECTS Lecture contents As an example from biotechnology, students will work in the brew lab to create a beer, following a recipe. Students will be introduced into the topic of brewing and will have the chance to see an automated solution and investigate the data produced by the equipment. Additionally to the work in the lab, students are required to design a label for their beer and create a website with the recipes they worked on.The students will work in groups of 3-4 persons. Assessment methods Students will be graded on their performance in the lab and the design of the label and web page. Teaching methods Presentation, praktical lab exercise Language German > Fermentation Practical LBBioprocess Technologymore Fermentation Practical LB Lector: Ing. Michael Geissler, MSc., FH-Prof. DI Dr. Michael Maurer, Maria Schrammel, BSc 1 SWS 2 ECTS Lecture contents Brewing at a Craft Beer Brewery:> Recipe design> Scale up 50L -> 10hL and comparison> QA/QC of brewing process> Filling - KEGs and bottles> Marketing Assessment methods Protocol Teaching methods practical course > Microbial Production Strains and Strain Developmen...Bioprocess Technologymore Microbial Production Strains and Strain Development VO Lector: FH-Prof. DI Dr. Michael Maurer, Dr.rer.nat. Christoph Metzner 1.5 SWS 2 ECTS Lecture contents Short introduction: Products, expression systems, marketsMetabolic Engineering: Aims, Prerequisites, Methods Optimising Product or Production?Focus Biomedicine: Antibody – Vaccine - Gene therapy vectorExamples from recent publicationsBottlenecks in Production/UpscalingMini seminar on Metabolic Engineering on a real-life example: „ Glycosylphosphatidylinositol-Protein Production for VLP vaccines – Assessing different strategies“ Assessment methods Final Exam Teaching methods Lecture - e-learning - mini-seminar - discussion Language German-English > Practical Course: Fermentation Technology LBBioengineeringmore Practical Course: Fermentation Technology LB Lector: Ing. Michael Geissler, MSc., Ing. DI (FH) Dr. Harald Kühnel, MSc, Dr. Christian Leitner, Dr. Nico Lingg, FH-Prof. DI Dr. Michael Maurer, Maria Schrammel, BSc 3.5 SWS 5 ECTS Lecture contents The course consists of two parts:1.Brewing technology2.Characterization of a recombinant yeast strainIn the course of the brewing technology, beer, liquor and vinegar are produced. This includes the process design, QA, filling and labeling.In the second part, a yeast strain producing lactic acid (outcome of the molecular biological lab) will be characterized in terms of productivity in comparison to the wild type and a mutant strain (PDC neg.) Assessment methods Written reports Teaching methods Laboratory Language German PublicationsThe publications of Michael Maurer written at FH Campus Wien can be found in our publication database, others in the personal web space.
> Bioreactors and Bioprocess Engineering ILVBioprocess Technologymore Bioreactors and Bioprocess Engineering ILV Lector: Hon.-Prof. Univ.-Doz. DI Dr. Rudolf Friedrich Bliem, FH-Prof. DI Dr. Michael Maurer 2 SWS 4 ECTS Lecture contents After the introduction, where the basic concepts and principles of bioprocess engineering are explained, the main bioreactor types and operation modes are presented. In the following section the kinetics of bioprocesses together with the underlying equations and graphs are outlined. Heat and mass transfer correlations, which are essential to be familiar with - especially for the design of bioreactors, are dealt in the following section. The characterization of various bioreactor types including enzyme reactors as weell as the upscaling principles are main topics of this lecture. Finally the basics of the sterilization technology and the design of SIP procedures are elucidated.The understanding as well as the benefit of the presented model equations for the particular unit operations are shown by some selected examples. Assessment methods Two written intermediate exams and a final test. Teaching methods The teaching is based on the following concept:First the scientific principles involved in a specific unit operation within biochemical engineering together with their practical application are elucidated. After a thorough discussion on the limitations of the respective Mathematical Model its practical value is shown by some examples.
> Biotechnological Seminar UEBioinformaticsmore Biotechnological Seminar UE Lector: FH-Prof.in Mag.a Dr.in Alexandra Graf, FH-Prof. DI Dr. Michael Maurer 0.5 SWS 1 ECTS Lecture contents As an example from biotechnology, students will work in the brew lab to create a beer, following a recipe. Students will be introduced into the topic of brewing and will have the chance to see an automated solution and investigate the data produced by the equipment. Additionally to the work in the lab, students are required to design a label for their beer and create a website with the recipes they worked on.The students will work in groups of 3-4 persons. Assessment methods Students will be graded on their performance in the lab and the design of the label and web page. Teaching methods Presentation, praktical lab exercise Language German
> Fermentation Practical LBBioprocess Technologymore Fermentation Practical LB Lector: Ing. Michael Geissler, MSc., FH-Prof. DI Dr. Michael Maurer, Maria Schrammel, BSc 1 SWS 2 ECTS Lecture contents Brewing at a Craft Beer Brewery:> Recipe design> Scale up 50L -> 10hL and comparison> QA/QC of brewing process> Filling - KEGs and bottles> Marketing Assessment methods Protocol Teaching methods practical course
> Microbial Production Strains and Strain Developmen...Bioprocess Technologymore Microbial Production Strains and Strain Development VO Lector: FH-Prof. DI Dr. Michael Maurer, Dr.rer.nat. Christoph Metzner 1.5 SWS 2 ECTS Lecture contents Short introduction: Products, expression systems, marketsMetabolic Engineering: Aims, Prerequisites, Methods Optimising Product or Production?Focus Biomedicine: Antibody – Vaccine - Gene therapy vectorExamples from recent publicationsBottlenecks in Production/UpscalingMini seminar on Metabolic Engineering on a real-life example: „ Glycosylphosphatidylinositol-Protein Production for VLP vaccines – Assessing different strategies“ Assessment methods Final Exam Teaching methods Lecture - e-learning - mini-seminar - discussion Language German-English
> Practical Course: Fermentation Technology LBBioengineeringmore Practical Course: Fermentation Technology LB Lector: Ing. Michael Geissler, MSc., Ing. DI (FH) Dr. Harald Kühnel, MSc, Dr. Christian Leitner, Dr. Nico Lingg, FH-Prof. DI Dr. Michael Maurer, Maria Schrammel, BSc 3.5 SWS 5 ECTS Lecture contents The course consists of two parts:1.Brewing technology2.Characterization of a recombinant yeast strainIn the course of the brewing technology, beer, liquor and vinegar are produced. This includes the process design, QA, filling and labeling.In the second part, a yeast strain producing lactic acid (outcome of the molecular biological lab) will be characterized in terms of productivity in comparison to the wild type and a mutant strain (PDC neg.) Assessment methods Written reports Teaching methods Laboratory Language German