Bioengineering

Lecture contents

Abreviated contents:
The Cell: General properties, systematics, Growth
Prokaryotes, Fungi and Algae
Microbial Habitats

For contents see above.

Assessment methods

Written Exam

Teaching methods

Combination of lectured course and film presentations

Language

German

Lecture contents

Elements and compounds; atoms and the periodic table of the elements; the chemical bond; molecular geometries; gases, liquids and solid state; preservation of mass and energy; chemical equilibrium; oxidation and reduction; coordination compounds; basics of chemical thermodynamic; main group and transition metal chemistry; environmental problems; important aspects of general and inorganic chemistry in biological systems.

Assessment methods

At the end of the lecture there will be a written examination

Teaching methods

Lecture with exercises

Language

German

Lecture contents

Introduction into Analytical Chemistry - Basics and Methods; validation
Classical quantitative analysis: gravimetry, titrimetry (Acid-base titrations, precipitation titrations, titrations based on complexation reactions, titrations based on redox reactions).Spectroscopic methods: AAS, AES, RFA, REM; UV/VIS, IR, MS, XPS, NMR.
Electrochemical methods of analysis: electrogravimetry, coulometry, conductometry, potentiometry, polarography.
Introduction to separation techniques (chromatography, electrophoresis)

Assessment methods

oral presentation followed by short written essay in small groups
homework/preparatory tasks from unit to unit
written exam at end of semester (planned on campus; but change to digital exam due to the current corona-situation possible)

Teaching methods

interactive class lecture
on-campus as well as distance teaching via "zoom"
homework/prepration tasks from unit to unit
oral presentations by students in small groups

Language

German

Lecture contents

The focus is gaining experience in important basic principles and physical-chemical procedures of analytic and quantitative chemistry as well as chemical basic operations.

Introductory part ( 7 exercises)

Assessment methods

An examination will be held after the finalisation of the introductory part.
The results of the written examination and the practices will be taken as basis for assessment.

Teaching methods

Practices; on-the-job training

Language

German

Lecture contents

- chemical bonds in organic chemistry
- basic concepts of organic chemistry
- introduction to organic compounds
- overview on functional groups
- basics of organic reactions

Assessment methods

written examination

Teaching methods

oral lecture

Language

German

Lecture contents

- Introduction into light microscopy / Structure and function of simple cellular systems.
- Cellular organization of microorganisms (yeast, bacteria) and plants / cell wall, typical organelles of higher organisms (e.g. nucleus, vacuole(s), ER, etc.) / Function of plasmatic and non-plasmatic components (e.g. osmosis, permeability, nutrient uptake, storage, etc).

Assessment methods

- After the course written examination about theoretical aspects and assessment of the graphical documentation (workbook) of the microscopy work / active participation

Teaching methods

- Powerpoint presentations / practical experiments in the microbiology laboratory

Language

German

Lecture contents

Following topics will be presented:

Atomic weight/molecular weight/mole /laws of stoichiometry/balancing chemical reactions/
redox reactions, solutions/units of concentration/Chemical equilibrium/Ideal Gases
Acids and bases and their salts, buffers, the pH-scale, and pH-calculation/Solubility
volumetric analysis/ Calibration Procedure and validation of Analytical Methods/
dilution/ buffer/ calculation of culture medium / exercises in photometric determination with calibration graph

Assessment methods

Three written midterm exams.
Some examples have to be calculated. If not, there is the possibility to repeat this examples.
Homework.

Teaching methods

Power Point is used to present the theory of the subjects, we calculate many exercises during the lecture, active collaboration is requested.
The script, the homework and additional exercises will be available in time on the moodle platform.

Language

German

Lecture contents

Repetition and strengthening of fundamental mathematical concepts and methods.
In particular, we will focus on the following items.

1. terms, formulas, variables
2. quantities and units
3. exponential functions, logarithm
4. geometry
5. basic linear algebra (vectors, matrices)

Assessment methods

written assignments

Teaching methods

lecture, exercises

Language

German

Lecture contents

equations
functions in one variable
differential and integral calculus
ordinary differential equations

Assessment methods

1. Active participation
2. Weekly homeworks
3. A final examination

Teaching methods

Lecture + Excersise

Lecture contents

1. Units and quantities
2. Mechanics
3. Thermodynamics
4. Electricity
5. Optics

Assessment methods

Written Exam

Teaching methods

Lecture

Lecture contents

1-dimensional data description:
Population and sample, numerical measures for location and spread, boxplot, absolute and relative frequency, empirical distributions.

Random variables:
Probability (axioms, addition rule, conditional probability, multiplication rule); discrete random variables (binomial distribution, hypergeometric distribution); continuous random variables (normal distribution).

Parameter estimation:
Estimation functions, confidence intervals (mean, standard deviation, probabilty).

Testing of hypotheses:
Introduction (alternative and null hypothesis, 1- and 2-sided hypotheses, types of errors, power);
1-sample problems (t-, binomial-test); test of normality (QQ-plot, Shapiro-Wilk-test); 2-sample problems (t-, F-test); sample size calculations (t-test).

Linear regression:
Bivariate normal distribution, Pearson correlation coefficient; simple linear regression (least squares estimation, test on linear relationship, coefficient of determination, regression through the origin, linearization methods); linear calibration functions.

Assessment methods

Written examination

Teaching methods

Lecture with case studies and exercises; accompanying text to lecture, collection of formulae and simulations programs (in R) for downloading.

Lecture contents

Bioorganic chemistry combines methods and techniques of organic chemistry and biochemistry to solve problems of biological relevance and it is inspired by biology when new biotechnological processes are developed.

- Introduction into Bioorganic Chemistry
- Description of the essential structural elements: nucleotides, amino acids, carbohydrates, lipids
(partly Repetition, but also advanced topics)
- Assembly and structure of peptides, proteins
- Glykoproteins in prokaryotic and eukaryotic organisms
- Biomembranes and their self-assembly
- Polyketides and terpenes
- Methods for characterization of these components as well as their biological and synthetic preparation.

Assessment methods

One final written final exam, mostly with open questions. It is planned to hold it in "Presence Mode", i.e. with physical attendance of the candidates and the examiner.

Teaching methods

Predominantly lecture style instructions, partly online via Zoom Meetings.

The slides will be made available to the students within the accompanying Moodle course; they are derived from both the suggested text books and the indicated literature references (on the slides).

Language

German-English

Lecture contents

During this course you will try some quantitative methods. The focus is gaining experience in important basic principles and physical-chemical procedures of analytic and quantitative chemistry as well as chemical basic operations.

Introductory part (+6 samples)
1. Sample: Knowledge Base - titration and uncertainty of measurement
2. Sample: Weak Acid, acidimetric
3. Sample: Gravimetric determination of iron
4. Sample: Water analysis - determination of water hardness
5. Sample: Distillation and determination of nitrogen content (Parnas-Wagner)

Assessment methods

An examination will be held. The results of the written examination and the practices will be taken as basis for assessment.

Teaching methods

Practices; on-the-job training

Language

German

Lecture contents

1. Sample: Conductometric determination of saltsolution
2. Sample: Potentiometric determination of the molecular weight of an amino acid
3. Sample: Determination of chloride beside jodide with an ion-selective electrode
4. Sample: Photometric determination of iron
5. Sample: Photometric determination of the pK-value of an indicator
6. Sample: Redoxtitration (Vitamin C, jodemetric)
7. Sample: Ion chromatography (chloride, nitrate and sulfat)

Assessment methods

Litte oral test before starting working.
An examination will be held at the end of the course.
The results of the written examination and the practices will be taken as basis for assessment.

Teaching methods

Practices; on-the-job training

Language

German

Lecture contents

-introduction to Fluid Dynamics
-physical properties of fluids
-fundamentals of hydrostatics
-hydrdynamics: conservation equations and pipe hydraulics
-sedimentation velocity
-pumps and pump design
- stirring

Assessment methods

Written exam at the end of the course. 1.5 hrs

Teaching methods

theoretical lecture with powerpoint and blackboard, practical examples

Lecture contents

The first part of the lecture will give an overview of the most important engineering materials as metallic- and no metallic materials as ceramic materials, glass, plastics and composite materials. This part is supplemented by the explanation of corrosion and corrosion protection.
in the second part production processes are discussed - casting and sinter, forging, rolling, milling, drilling, sawing and grinding, welding, soldering and bonding.
in the last part of lecture machine elements are discussed.

Assessment methods

Examination

Teaching methods

lessons

Language

German

Lecture contents

Overview on methods in microbiology as a detailed preparation for the practical courses ('Laborpraktikum')
1. Aseptic techniques
2. Cultivation of MO
3. Identification of MO
4. Determination of growth kinetics
5. Antibiotics

Assessment methods

Final written examination

Teaching methods

Lecture with practical application examples

Language

German

Lecture contents

1. Structural untis of organic compounds (hybride orbitales, molecular orbitales)
2. Reaction mechanisms
3. Alkanes (characteristics, introduction to nomenclature, reactions, synthesis, sources, representatives)
4. Alkenes (isomerism, reactions, representatives)
5. Alkynes (representatives, characteristics, sources, reactions)
6. Halides (characteristics, synthesis, representatives, reactions)
7. Alcoholes (characteristics, synthesis, reactions, representatives of mono- and polyols)
8. Ethers (characteristics, synthesis, reactions)
9. Sulfor containing compounds
10. Amines (characteristics, synthesis, reactions, representatives), further N- and P-compounds
11. Aldehydes and ketones (characteristics, synthesis, reactions, representatives)
12. Carbonic acids (characteristics, synthesis, reactions, representatives)
13. Derivatives of carbonic acids (halides, esters, amides, anhydrides)
14. Amino acids and peptides
15. Aromatic Compounds (aromaticity, characteristics, reactions, representatives)
16. Dicarbonic acids
17. Hydroxy carbonic acids
18. Organometallic Compounds
19. Natural Compounds (carbohydrates, fats, oils, waxes, terpens, nucleic acids)

Assessment methods

recurring tests, exercise examples and final examination

Teaching methods

oral lecture

Language

German

Lecture contents

In the first part we introduce procedures for solving mathematical problems relevant for applied natural sciences.
- Systems of linear equations
- Error estimation
- Zeros of real functions
- Interpolation, numerical differentiation
- Integration
We will treat the theoretical background as much as necessary for the practical understanding and
master the different techniques by demonstative examples. For solving more complex problems we will use the computer.

The second part of the course will deal with applied mathematics where the theory from Hydrodynamics is used to analyze real world examples.

Assessment methods

written exam + practical exercises

Teaching methods

Presentation; calculations of examples on the blackboard and with the aid of the computer.

Language

German

Lecture contents

As a basic course of Mechanical Engineering, the following content has to be conveyed:

1) instrcution to technical drawing
2) descriptive geometry (2D, 3D, sectional views, dimensioning)
3) details for manufacturing (tolerances, fits, connections, surface processing, welding symbols)
4) process flowcharts (basic flow chart, process flow diagram, P&ID)

Assessment methods

There will be no written exam within this course. The assessment will be based on the level of cooperation and a written home exercise.

Teaching methods

lecture with case studies and partly short exercises.

Language

German

Lecture contents

This course will present the following aspects of applied microbiology based on selected examples:
microoorganisms in association with Foods
microorganisms in the environment
pharmaceutical indicator organisms
production strains for biopharmaceuticals

Assessment methods

Written final exam

Teaching methods

Lectured course and distant learning

Language

German-English

Lecture contents

Fundamentals of Electrical Engineering
Applications of Electricity
Fundamentals of Electrical Engineering
Basic electrical variables
Ohm's law
Electric power, work, efficiency
The electrical circuit of consumers
Measuring electrical variable
Types of current
Power and safe handling of electricity
Pipework and electrical connection
Electrical Installation and Connections
Protective measures for electrical equipment
Possible errors on live equipment
Dangers of Electricity
Safe handling of live wires and machines
Symbols on electrical machines DEVICES AND
Electric drive equipment in chemical plants
electric motors
Three-phase motors
DC motors
Types of motor protection

Assessment methods

Written Exam

Teaching methods

Lecture with media support (power point slides). Accompanying Exercises and demonstration material e.g. sketching of circuits sketch and calculations, measuring instruments,..

Language

German

Lecture contents

Applied Material Technology
- Characteristics
- Metallics
- Plastics
- Keramisch
- Surface Technology
Machines
- Pumps
- Agitators, Mixer
- Homogenizers
- Centrifuges
- Machine Safety
Equipment
- Pressure Vessels
- Filter Housings
- Heat Exchanger
Water Treatment
- Pretreatment
- Filtration
- Destillation

Assessment methods

Written exam. Oral exam if written test negative.

Teaching methods

Lecture with Powerpoint-presentation (presentation documents will be provided). Focus on presentation of examples out of industrial practice. Discussion and experience exchange of the students under presentation of the lector. Appliance of lecture contents in training examples.

Language

German

Lecture contents

Fundamental operations of mechanical-thermal Process Engineering are discussed in ths lecture. Energy Management and technical Thermodynamics, mechanical separating processes, thermal separating processes, physico-chemical separating processes.

Assessment methods

written exam

Teaching methods

Lecture

Language

German

Lecture contents

Knowledge on basics of molecular genetics:

What are living organisms made of - in a biochemical sense - what molecules - which compartments and structures? How are these molecules, compartments and structures passed on to offspring?
How do living organisms function in a chemical and physical sense? How is this live "steered"?
How identical are offspring to their parents, or how different?
How is genetic and biological relationship explained on the molecular level?

Topics in the Basics part:
- Historical perspective - Genomics, Transcriptomics, Proteomics
- Differences between Eukaryota, Porkaryota, Archaea, and Viruses
- Replication - Transcription - Translation
- Mutations and Recombination

Methods included in this part:
- Sequencing technologies

Assessment methods

Moodle exam

Teaching methods

Lecture

Language

German

Lecture contents

Autonomous solving of problems related to the lecture Mechanical-Thermal Process Engineering

Assessment methods

Participation

Teaching methods

autonomous calculation of exercise examples, supported by tutors

Language

German-English

Lecture contents

Mathematical examples for process engineering operations

Assessment methods

written exam

Teaching methods

demonstration of mathematical examples with student participation, homework, distance learning

Language

German

Lecture contents

Introduction into microbiological techniques:
Working under sterile conditions
Different cultivation techniques (surface cultures, liquid cultures)
Cell number determination (according to Koch, Thoma chamber)

Preparation of microbial media

Morphology:
Microscopic imaging of bacteria, yeast and filamentous fungi
Staining techniques. Gram, capsule and spore staining

Physiology:
Growth of yeast on different carbon sources (C-auxanogram)
Antibiotics testing (diffusion test, commercial test stripes, dilution method)
Api test (physiological identification of bacteria with different biochemical tests)

Growth kinetics:
Growth characteristics of E. coli

Assessment methods

Bonus system for practical courses. Final written examination (joint exam with MiMe)

Teaching methods

Practical course; in the first part, the students perform experiments under guidance of the lecturers; in the second part, the acquired skills have to be applied in order to autonomously identify an exemplary germ

Lecture contents

Basic substances in Biochemistry (Short repetition from SS): Carbohydrates, amino acids, lipids, nucleotides; isomerisms, electrolytes
Peptides and proteins: Composition, structure, function
Overview of protein methods
Hemoglobin
Enzymes: Basics, catalysis, mechanisms, kinetics, inhibition, regulation
Intermediary metabolism: Basics, energetic considerations
Important metabolic pathways:
Carbohydrate metabolism: Glycolysis, fermentations, citrate cycle, calvin cycle, pentose phosphate pathway, glycogen
Lipid metabolism: Fatty acids, cholesterol
Biological membranes
Respiratory chain and oxidative phosphorylation
Overview of amino acid and nucleotide metabolism; cata- and anaplerotic reactions
Nitrogen metabolism, urea cycle
Photosynthesis
DNA and RNA: Structure and function
Replication, transcription
Translation, posttranslational modifications
Regulation of gene expression
Optional: Molecular machines, intracellular sorting of proteins, signal transduction, immune system

Assessment methods

One interim test and a final exam. Single/multiple choice questions and open questions mixed. Details to this matter will be discussed in the lectures.

Teaching methods

Predominantly lecture style instruction. The slides used will be made available to the students within the FH Portal; they are mainly derived from the suggested text books

Language

German-English

Lecture contents

Methods for Proteins:
- Total protein concentration
- Immunochemistry (ELISA)
- Electrophoresis
- Chromatography
- Mass spectrometry

Enzyme kinetics
- Km-Value
- Reaction rates

Nucleic Acids

Assessment methods

Homework, In-class contribution, Final Exam

Teaching methods

Lecture with practical examples, which are done in the form of short projects during lectures or as part of homework

Lecture contents

Chemical Calculations, NiNTA Chromatopraphy, Dialysis, Enzyme activity assays, Enzyme kinetic assays, SEC and HPLC, Protein quantification (Bradford, OD280), SDS-PAGE, Western Blot, ELISA

Assessment methods

In-class participation and written protocols

Teaching methods

Practical training accompanied by discussion and reflection rounds

Language

German

Lecture contents

Bioprocess Engineering Principles

Assessment methods

Final Exam

Teaching methods

Practical, presentation

Language

German

Lecture contents

Brewing Technology:
Raw materials in brewing. Enzymatic processes during malting, mashing, boiling and fermentation&storage of beer. Filling technology in beverage industry.
Analyses and assessment of quality control in breweries. beer design.
beer tasting.

Assessment methods

Written exame

Teaching methods

Lecture

Language

German

Lecture contents

Biological Expressionsystems
Cell Banks
Media Development
Sterilisation
Reactor Engineering
Mass Balances
Bioprocesses Batch, Fed Batch and Chemostat
Scale up, Process Design

Assessment methods

final exame, written

Teaching methods

Lecture

Language

German

Lecture contents

Basic concepts of measurement, principles of electrical measurement of quantities with significance in biotechnological processes.
Basics of sensor elements.
Fundamentals of process automation, process control, in particular, programmable logic controllers (PLCs) and field bus systems.
Introduction to the fundamentals of control theory, types of control systems, analysis, design and simulation of control loops.

Assessment methods

Written test at the end of the lecture.

Teaching methods

Lecture, design and calculation exercises with Excel and simulation programs.

Language

German

Lecture contents

Industrial application of microorganisms and Industrial Bio-Products
Primary and secondary metabolites
Antibiotics
Enzymes and other products

Betalaktams
Biosynthesis of Penicillin and Cephalosporin and strains
Early development
Mould-based Production Technology, productivity and economic constraints
Selected process control parameters
Aspects of Scale-Up
Downstream Processing
Isolation, purification, pharmaceutical tabletting
Regulatory framework and Summary

Assessment methods

Final written examination

Teaching methods

lectured course

Language

German-English

Lecture contents

The cell (Organization, cell compartments, Cytoskeleton); cell membrane (structure, properties, lipid and protein components, transport mechanisms); cell organelles.; cell nucleus, storage and information, gene therapy; proteins and their manifold functions; Bioenergetics; cell Division; Tissues; Cellular components of the immune system, genetic and epigenetic mechanisms to control cellular behavior

Assessment methods

Written Exam

Teaching methods

Powerpoint slides
Discussion rounds following each chapter, to reflect on the presented information

Language

German-English

Lecture contents

Theoretical part:
Immunological techniques like ELISA, SPR, Western-blot, Protein-arrays, IHC, …
Techniques of cell biology like fluorescence microscopy, FACS, counting of cells, …
Fundamental biochemical techniques like determining the concentration of protein solutions, …
And instrumental analysis-techniques like electrophoresis, capillary-electrophoresis, FPLC, HPLC, Proteome-analysis, … .
DNA-analysis: qPCR and digital PCR

Part Schlager:
Extraction and analysis of Proteins by FPLC
DNA-analysis: staining of DNA, sequencing, electrophoresis, ....

Practical part:
Students will solve bio-analytical problems by using recent literature (pubmed, …) and condense their findings in a 20-minute lecture including literature citrates.

Possible bio analytic questions:
What are exosomes, find out how exosomes can be extracted out of ascites. Describe at least two possible extraction methods. Finally, you should prove that you did a successful extraction and yielded an as clean as possible exosomal fraction without contamination with lipoproteins.

Assessment methods

Exam at the end of the lecture active participation, speeches

Teaching methods

lecture and group work

Lecture contents

1. In this lecture we talk about what Bioinformatics is and why we need it today.
2. Basic concepts of programming will be discussed and with hands on exercises illustrated.

We will go through specific topics of Bioinformatics and discuss the available applications. The topics include:
- Why did Bioinformatics develop and what is it.
- Human Genome Project and its consequences
- Biological sequences, sequence comparison and database search.
- Pattern search
- Structure of biological sequences and structure prediction
- High throughput technologies and data analysis

Assessment methods

Exercises and short test at end of the lecture

Teaching methods

lecture, powerpoint presentation, discussion and hands on exercises

Lecture contents

Terms, principles, concepts and practice of today´s Quality Management and in particular of good manufacturing practice;
processes and operating procedures, manufacturing documents;
models and Standards;
the concept of error and its general relevance;
GMP: legal Framework and purpose;
selected subjects and aspects of GMP.

Assessment methods

Written exam + practical exercise

Teaching methods

Lecture with discussion
Homework

Language

German

Lecture contents

Construction of an expression vector to produce l-lactic acid in Saccharomyces cerevisiae
1.) Isolation of the l-lactat-dehydrogenase gen form Lactobacillus plantarum
2.) Construction and amplification of the expression vector in E. coli
3.) Transferring the expression vector in the target organism S. cerevisiae and measurement of the LDH activity

Assessment methods

Writing a scientific lab protocol
Recommended language: German or English
Rated will be the protocol and the practical work in the lab.

Teaching methods

After a theoretical introduction at the beginning of each lab day the students will conduct the experiments by themselves with help from the protocols.

Language

German

Lecture contents

Goal:
Establish a plan to produce lactic acid in yeast. Develop a concept including all relevant points and present it to your client.

Goal of this seminar is to clone the L-lactat dehydrogenase gene (LDH, EC 1.1.1.27) into a yeast strain. This will lead to a transgenic organism capable of producing lactic acid.
Plan all necessary steps to produce this strain:
Which yeast will you use? From where will you get it?
LDH: From which organism, where/how will you get the gene?
Vector: Which essential part must the vector contain? Where will you get it, buy, construct….?
How can you clone the LDH gene into the vector? REN, cutting sites, primer….
Which transformation method will you use?
How will you screen for positive transformants? Isolation, master cell bank…
How will you prove the correct gene transfer and the production of lactic acid?
The concept can/should be individual and in theory functional. There is no silver bullet (yeast strain, LDH gene, cloning, transfer, vector, detection…). Lively discussion between colleges is encouraged. Identical or recycled concepts from previous year will not be tolerated!
At the end the concept will be presented to your colleges in the frame of a short presentation.
Length of the written presentation: 2 Pages.

Assessment methods

Graded will be the writen concept and the presentation.

Teaching methods

Independent preparation of the concept and the presentation, training and time for Q&A during the lectures

Language

German

Lecture contents

The course consists of two parts:
1. Brewing technology
2. Characterization of a recombinant yeast strain
In the course of the brewing technology, beer, liquor and vinegar are produced. This includes the process design, QA, filling and labeling.
In the second part, a yeast strain producing lactic acid (outcome of the molecular biological lab) will be characterized in terms of productivity in comparison to the wild type and a mutant strain (PDC neg.)

Assessment methods

Written reports

Teaching methods

Laboratory

Language

German

Lecture contents

This course is aiming two major goals:
First of all to develope a common understanding in quality-control-systems conserning the differences to general analytics. Secondly, to deepen the knowledge and background of quality relevant principles and requirements. Methods in breweries quality control, representative for food essentiell quality control will be addressed. Main topics are dealing with laboratory organization, equipment management, Method development and error analysis.

Assessment methods

Homework and discussion: 40%
Final, written examination: 60%

Teaching methods

This course has been established as an interactive workshop:
To reach the intended aims, each student has to do several home-exercises in respect to introduced topics which need to uploaded. According to the objectives of the course I will introduce the methods and quality related concepts. Interaction, respectively discussion is desirable.

Language

German

Lecture contents

Kühnel

1. Isolation of cells
2. Hayflicklimit, telomeres and telomerase
3. Specialised cells
4. Immortalisation of cell lines
5. Tissue engineering, Organkultur

Weilner
1. Cell culture laboratories, steril technique and cryoconservation
2. Cultivation methods, cell number, media and components
3. Cell line characterisation
4. Application of animal cell lines and development of recombinant cell lines

Assessment methods

written

Teaching methods

Classroom lecture

Language

German-English

Lecture contents

Review of elementary concepts and methods;
confidence intervals and tests (confidence intervals for binary variables, robust statistics, outliers, equivalence tests);
acceptance sampling ( sampling plans for attributes and variables);
control charts;
simulation experiments (confidence intervals, bootstrapping, p-value, power);
design of experiments (parallel design, one-way ANOVA, simple linear regression, calibration experiments, inter laboratory tests.

Assessment methods

Written examination

Teaching methods

Lecture combined with exercises

Lecture contents

Case studies from the following subject areas:
Acceptance sampling for attributes and variables in food production, confidence intervals and tests, Monte Carlo simulations, statistical process control, analysis of experiments, inter laboratory tests.

Assessment methods

Presentation and written report.

Teaching methods

Short inputs about the topic of the projects (background, statistical methods, R-specifics). Statistical consulting during the working out of the project.

Lecture contents

Process equipment for upstream, recovery and downstream process, as well as for process supply and central utilities
Piping, armatures and valves
Building concept / plant layout / hygiene concept
Cleaning and sterilization
Automation
Planning process
Qualification

Assessment methods

- Presence in the lecture
- Written final test (positive grading in case of > 60% of possible points)
- Oral examination in case of negative test result
- Unexcused absences (> 20%) or unexcused no-show to examination equivalent to a negative test result

Teaching methods

Lecture with power point presentation

Language

German

Lecture contents

The course will be held in German - see German description

Assessment methods

Written exam, assignements

Teaching methods

The course will be held in German - see German description

Lecture contents

Introduction to the working environment with Linux, R and Python.
Introduction to concepts of version control with Git and working on a Linux Server environment.

Assessment methods

practical programming task

Teaching methods

lecture (powerpoint)
practical work using computers

Language

German

Lecture contents

Introduction in Programming with R and the analysis of biological datasets:

R topics:
- Data types
- Control structures
- Functions
- Packages
- Plots

Assessment methods

Exercises in DataCamp and through Moodle

Teaching methods

Lecture and Exercise. Accesss to DataCamp.

Language

German-English

Lecture contents

This course is the first course for a student planning to study computer programming. The course content introduces the student mainly to both procedure-oriented and with basics on object-oriented programming languages.
Structured programs will be written with a computer programming language (Python 3) with an emphasis on procedure-oriented programming. Topics will include basic computer hardware architecture constructs, flowcharting, pseudocode, top down design, logic structures, data structures and types, decisions, subroutines, looping, sequential file processing, data collection types and building basic graphical user interfaces.

Assessment methods

The final exam will consists of 2 parts:
1. A multi-choice test on all the arguments covered during the lectures
2. A small programming exercise on the PC

Teaching methods

The course will consist of frontal lectures and in-classroom programming on PC using Python 3 as programming language.

Language

German

Lecture contents

The course addresses the technology of GMP-compliant manufacturing aseptically prepared sterile liquid pharmaceutical products and methods to assess the process performance.

Assessment methods

Concurrent performance assessment via blended learning tasks and permanent review of content already bespoken incl. solving examples to demonstrate the ability to apply the content practically.
If less than 60 % of the required performance were provided before the final exam in addition, directly following the final exam an additional oral examination has to be performed. This will be communicated the students affected in an appropriate manner (via Moodle, by mail).

1st test date: Written final exam (multiple choice, formulated questions and calculation examples).
Generally, further dates (not exam attempts!) of the final exam are conducted as oral exams.
The test modality will be announced with the test date.

Weighting of the final grade:
Final Exam 60% and blended learning tasks 40% (each part must be completed with a positive grade)

Teaching methods

Lecture (SS21 as distance learning via Zoom) and blended learning
The lecture slides and additionally the comments of the lecturer during the lecture are the basis of the course content. Those will be additionally completed with the content (documents, videos, podcasts, internet links, ...) for the blended learning tasks.
The sum of this all is relevant for the blended learning tasks (i.e. permanent progress check) and the final exam.

Language

German-English

Lecture contents

Good Manufacturing Practice (GMP) forms a quality framework for the production of pharmaceutical and biotechnological products. Plant Hygiene represents a central pillar of GMP, both in the way of general principles for avoiding adventious product contamination and through specific forms of implementation and instruments.

Assessment methods

Concurrent performance assessment via blended learning tasks and permanent review of content already bespoken incl. solving examples to demonstrate the ability to apply the content practically.
If after the last lesson before the written final exam less than 60 % of the required performance were provided in addition, following directly the final exam an additional oral examination has to be performed. This will be communicated the students affected in an appropriate manner (via Moodle, by mail).

1st test date: Written final exam (multiple choice, formulated questions and calculation examples).
Generally, further dates (not exam attempts!) of the final exam are conducted as oral exams.
The test modality will be announced with the test date.

Weighting of the final grade:
Final Exam 60% and blended learning tasks 40% (each part must be completed with a positive grade)

Teaching methods

Lecture (SS21 as distance learning via Zoom) and blended learning
The lecture slides and additionally the comments of the lecturer during the lecture are the basis of the course content. Those will be additionally completed with the content (documents, videos, podcasts, internet links, ...) for the blended learning tasks.
The sum of this all is relevant for the blended learning tasks (i.e. permanent progress check) and the final exam.

Language

German-English

Lecture contents

Downstream processing means the treatment or purification of fermentation products.
The lecture explains procedural basic operations as well as the purification and separation processes of metabolites.
Emphasis is placed on mechanical and thermal separation processes, their application areas and their use on the industrial scale.
On the basis of the general methods, special cleaning steps are also shown.

Assessment methods

written examination

Teaching methods

Lecture and discussion

Language

English

Lecture contents

The aim of this course is the design, operation and analysis of a controlled bioprocess. Therefore, the recombinant E. coli strain will be cultivated in a batch fermentation.

Assessment methods

- colloquium

- report

- active participation

Teaching methods

group work

Language

German

Lecture contents

The completion of an internship is part of the course of studies.

Assessment methods

Further information: see portal downloads (only accessible for students, other people interested can inquire information in the office of the study program)

Teaching methods

Further information: see portal downloads (only accessible for students, other people interested can inquire information in the office of the study program)

Lecture contents

Basics about downstream processing of proteins including impact factors and quality requirements
Basics about important methods e.g. centrifugation, filtration, cell disruption, precipitation, chromatography
Calculations of processes

Assessment methods

written exam incl. calculation

Teaching methods

lecture

Lecture contents

Mentoring during the professional practical training

Assessment methods

written report

Teaching methods

Seminar

Lecture contents

see german description

Assessment methods

See german description

Teaching methods

Seminar, homework

Language

German

Lecture contents

The recombinant proteins produced in the fermentation laboratory course will be purified with typical unit operation. The course covers homogenization, centrifugation, chromatography and ultra-/diafiltration.

Assessment methods

- Colloquium

- Protocol

- Participation

Teaching methods

Pactical course in groups

Lecture contents

See german description

Assessment methods

see german description

Teaching methods

See german description

Lecture contents

Lecture part about system softwares:
The operating system Linux is essential in bioinformatics. This lecture and exercise provides an introduction to Linux in general and the usage of the operating system in particular

Data base systems:
- Theory:
In this part we will learn the basics of relational data base systems and SQL.

- Training:
The training will take place in small groups. The purpose of the training session will be to set up a small use case with MySQL.

Assessment methods

Lecture part about system softwares:
written exam and complete and punctual delivery of exercises. The grade will be calculated from exam and excercises 70%/30%.

Data base systems:
Written exam. The grade will be calculated from exam and excercises 70%/30%.

Teaching methods

Lecture part about system softwares:
Lecture and exercises during lecture time and at home

Data base systems:
Lecture and exercises during lecture time and at home

Language

German

Lecture contents

The lecture is meant to support the students in their bachelor thesis, the content is dependent on the topic the student has selected.

Python (Norbert Auer):
Based on the programming lectures so far, this lecture finalizes important programming concepts with Python. Practical examples from different areas, such as functions, class hierarchies, polymorphism, interfaces, exceptions, modules, and file in/output, are presented and practiced.

Assessment methods

This lecture is the basis for the bachelor thesis and will be appraised together with it.

Teaching methods

Presentation and dialogs,
interactive work and studies,
practice on our notbooks

Language

German

Lecture contents

In the lecture students will be supported in the research into the biological topic of their bachelor thesis. The written format of the bachelor thesis will be explained and the scientific process of writing a thesis will be introduced.

Assessment methods

Final presentation by the students

Teaching methods

Presentation, discussions

Language

German