The English language Master degree program builds on the Bachelor degree program of the same name with the aim of further strengthening your knowledge of modern molecular biology. You will become a specialist with entrepreneurial skills in the field of molecular biology and human-oriented biotechnology. The degree program focuses on immunology or drug discovery. You will research the causes and effects of diseases in depth and understand new procedures and therapies are developed. Your world is research and development in the field of red biotechnology with prospects for taking on management positions.
Elisabeth HablasCampus Vienna Biocenter Helmut-Qualtinger-Gasse 2 1030 Vienna T: +43 1 606 68 77-3500 F: +43 1 606 68 77-3509 firstname.lastname@example.org
Office hoursMon-Wed, 8.00 a.m.-12.00 noonThu, 9.00 a.m.-12.00 noon and 1.00 p.m.-6.00 p.m.Fri, closed
Application period for academic year 2018/19
1st October 2017 to 14th June 2018
tuition fee / semester:
+ ÖH premium + contribution**
* Tuition fees for students from third countries € 727 per semester
**for additional study expenses (currently up to €83 depending on degree program and year)
Your interest in breaking new ground in the development of vaccines or medicines or areas such as stem cell research and a desire to take on management responsibilities are very good prerequisites for attending this degree program. You want to be at the forefront of developing new technologies. You are not looking for routine work, but major challenges in research and development. You are a very curious and frustration-resistant individual who wants to examine things extremely closely and you have the patience to take the many necessary steps to reach your findings. You are aware that alone you can achieve a lot, and in a team you can achieve everything. English as the language of life sciences is part of your everyday working life.
Located at the Campus Vienna Biocenter, you will be able to study and conduct research in state of the art lecture halls and laboratories. You will have access to the best equipment in Central Europe, including among other things an S2 laboratory (the second highest safety level). We share this important life sciences center with numerous research institutions and well-known biotech companies and maintain an active exchange of knowledge. For example, lecturers from the Vienna Biocenter integrate the latest results in stem cell research directly into their teaching. In addition, your education and research benefit from our close partnerships with the University of Vienna and the Medical University of Vienna. We have built a strong international network that provides you the opportunity to study or conduct research at prestigious universities such as King's College or Imperial College in London, among the top 10 universities in the world. Numerous R&D projects in the degree program offer you the opportunity to participate in application-oriented practical research and to make valuable contacts for your future career. Practical relevance is also guaranteed at our Campus Lecture evenings, which are open to all and feature contributions from prominent experts.
The Department of Molecular Biotechnology is active in medical and pharmaceutical research. Your education benefits from the results of our already established research fields: allergy research, cell-based test systems and signaling pathways of the cell. You will have the opportunity to participate in in vivo experiments in the fish model system. With the help of the fish it is possible to answer questions about functional genomics research and drug screening. Together with the Medical University of Vienna, we use the fish embryos to explore the regulation of the heat shock pathway after burns to improve their treatment. In allergy research, we focus on food allergies.
In addition, we are researching the pathological mechanisms of inhalational allergies, such as pollen allergies, with the help of epithelial cell culture systems. Together with the biotech company Ugichem, we are testing new concepts for peptide nucleic acid (PNA) applications to influence the molecular mechanisms of diseases such as cancer. And those are just recent examples. Thus, the degree program is not only a strong foundation for medical and pharmaceutical research, but also for a doctoral program at a university.
Lector: Dr.in Mary Grace Wallis, FH-Prof. Dr. Paul Watson
The timetable for this semester will be provided as detailed information sheets and will be discussed during the first lesson.See also below (Objective of the course).
Your command of English, both spoken and written, will be continuously assessed during the semester and will be reflected in the final semester mark. Moreover your active participation in the lessons will also contribute to the overall mark.
Spontaneous and prepared presentations. Brainstormings, Discussions, Debates. ‘Language clinics’. Individual, pair- and group-work.
Lector: DI Franz Gatterer, MBA
Content of a Businessplan (description of business case)- product and/or service- market anaylses- marketing- management and key/core kompetences needed- SWOT as bases of decisions- planning of implementation- investment required
Evaluation of group results (written businessplan). On top of this, individual interviews with students about their results allow to adjust quality on an individual level.
Groupwork: Students develop businessplan according standard model for technology intensive buseinss cases.Permanent interaction within teams but also between groups.
Lector: Prim.Univ.Doz. Dr.med. Johann Feichtinger
Principles of general pathology including representative examples of organ pathology;basics in morphology and clinico-pathologic correlations;nomenclature and systemics of diseases;methods applied in diagnostic pathology;
Written multiple choice test
Lector: Ao.Univ.-Prof. Mag. Dr. Dietmar Abraham, Nicole Glück, Heidi Miedl, Ao.Univ.Prof. Dr. Martin Schreiber, Andrea Steinbauer, BSc MSc, Ao.Univ.Prof.Dr. Rotraud Wieser
Course participants shall acquire and deepen their knowledge and understanding of the background and use of genetic analysis for medical purposes. Three specific examples of widely used methods will be presented in detail by the course instructors, focussing on the details of practical performance of such methods. Course participants shall further develop the practical skills and expertise to apply selected modern molecular genetic methods in the laboratory in small teams following manuals and laboratory protocols provided: the reverse transcriptase polymerase chain reaction to demonstrate the presence vs. absence of leukemia associated fusion transcripts; multiplex PCR followed by hybridisation to immobilised allele specific oligonucleotides to detect mutations in the Cystic Fibrosis Transmembrane Regulator gene; and genotyping of a single nucleotide polymorphism (SNP) in a patient collective and application of relevant statistical methods to correlate laboratory results with disease risk.
There will be no formal exam. Attendance to the course, level of active participation, as well as accuracy and completeness of the laboratory protocol will be evaluated.
Laboratory course with introductory lectures. Statistical evaluation of laboratory data.
Lector: Ao.Univ.Prof. Dr. Martin Schreiber
By critically reading selected key scientific publications, students shall acquire knowledge and understanding of current methods and medical applications of genetic analysis. After an introductory lecture by the lecturer, each participant will work in a small team to present a selected publication from a common topic to the class in a “journal club” format, followed by a detailed discussion by all participants.
Critical reading and oral presentation of the selected publication(s); Attendance; Active participation in the discussion sessions; Final written exam.
Introductory lecture by the instructor to the common topic; critical reading of a selected publication, preparation of a powerpoint-presentation of this publication, and oral presentation to the class; Active participation in the discussion of the own presentation and of those of the other participants (“journal club” format). Students may choose to give their presentation in either German or English.
Lector: Univ.-Prof.i.R. Dr. Christine Mannhalter
At the end of the lecture- The students know the basics, the areas of application, and the classical and modern methods of molecular genetics that are currently used in medical diagnostics. - They will know several diseases where a genetic component is causally involved and will know how to approach its analysis.- They will be able to differentiate monogenetic from polygenetic and acquired diseases (e.g. cancer) and will be able to decide on the type of analysis.- They will know how genes are associated with human diseases.
Preparation of a written manuscript to a specific topic, evaluation of the participation in discussions
Use of Power Point Presentation, regular discussions, use of quiz
Lector: Dr.in Anja Friedrich, Mag. Dr. Walter Glaser
The course teaches the basics of computer use in modern molecular biology research: search, download and analyze DNA and protein Sequnezen using local and Internet-based resources. Preparation of plasmid and prediction of restriction analysis, genomic resources, GO.Dealing with literature data, display structures, sequence search (Fasta, Blast)Databases: NCBI, EBI, PDB, Expasy, OMIM, others
protocol, Report of Results
Lector: Dr.in Anja Friedrich
We will go through specific topics of Bioinformatics and discuss the available applications. The topics include:- The Human Genome (Genomanalysis: SNPs, Variant Discovery)- Biological sequences, sequence comparison- Biological Databases- Data Formats- Protein domains, regulatory patterns- non-coding RNA prediction- gene set analysis
Written test on the theoretical part
lecture, powerpoint presentation, discussion and hands on exercises
Lector: FH-Prof.in Univ.Doz.in Dr.in Ines Swoboda
The lecture deals with the representation of the complex interactions between host and pathogen during infectious diseases. First, the defense mechanisms of the host, the innate and the adaptive immune system, are examined in detail. Then strategies of infection developed by pathogens to overcome host defense, survival and spread are presented. On the basis of model organisms infectious diseases caused by bacteria, viruses, fungi, protozoa and parasites are discussed in more detail. Furthermore, diagnostic and clinical aspects and fundamentals of antimicrobial and antiviral therapy are discussed. Finally, the principles and the most important basic concepts and methods of epidemiology are presented.
Knowledgemanagement for R&D- Knowledge definitions "stairs of knowledge"- Types of Knowledge (Nonaka/Takeuchi /Polanyi)- Approache of knowledge modelling- perspectives of KM- the SECI model and its meaning for R&D- components of KM- WEB20 options for KM- KM and processes of implementation and evaluation
brief study on R&D KM topics - realized with Mahara platform
FH-Portal für Sekretariate.htm
Lector: Monika Frauwallner, DI Franz Gatterer, MBA, Dr.in Mary Grace Wallis, FH-Prof. Dr. Paul Watson
• Students learn to fully recognize the richness of diversity, to find synergies and to capture and use them.• Students from different countries, from different cultural backgrounds, from different universities, from different disciplines, of different genders and with individual life experience become acquainted. Through mutual exchange they, and their fellow students, experience those strengths and weaknesses that play a role in their education/profession.• In a team the requirements of the studies are recognised and developed, compared with the individual’s own strengths and weaknesses and thus, the expertise developed to independently form teams and devise courses of action for specific tasks.
• Comprehensive principle of systemic thinking.• Diversity Management.• Competence-oriented teaching and examination: The students are themselves the focus through collaborating in teams during the teaching of theory and working on problems. While developing their results self-reflection and peer feedback are applied. Methods such as brainstorming, active structuring and discussions (while problem solving and getting to know each other), flashlight (for feedback) and expert interviews are used.• Knowledge management.• Team building.• Project management.• Transcultural competence
Lector: Andrea Steinbauer, BSc MSc, FH-Prof. Dr. Herbert Wank
RNA Methods: Experiment 1: Nothern Blot (Glucose/galactose metabolism in yeast, RNA extraction from yeast, denaturing RNA agarosegel, RNA transfer, specific oligonucleotidehybridazation, band detection)Experiment 2: EMSA (in vitro transcription with T7 RNA polymerase, RNA purification, RNA folding, native polyacrylgelelectrophoresis, RNA staining with methylblue, detection of the RNP complex)Experiment 3: RNA stability. The RNA stability is tested by incubation RNA under different conditions. The stability will be analysed by agarose gel electrophoresis.
The grade combines: Presence, motivation, enthusiasm, practical skills, written protocol.
Lector: FH-Prof. Dr. Herbert Wank
RNA basics, RNA structure, catalytic RNAs, RNA processing, RNA splicing, RNA editing, Riboswitches, RNA applications, Non-coding RNAs, RNA world, SELEX
wirtten exam at the end of the lecture course
Lector: Ao. Univ. Prof. Mag. Dr. Jozefa Gadek-Wesierski
This course offers an overview on the changes and disturbances of the proper regulation of the cell cycle progression and on the dysfunction of the induction and execution of the programmed cell death which occur during the malignant transformation and finally lead to cancer development. Moreover, it includes the description of the most important post-translational modifications of proteins and their role in the functional regulation of distinct proteins involved in the signal transduction. It gives an understanding of the expression and the function of tumour suppressor genes and proto-oncogenes as well as the changes of their regulation (inhibition or constitutive activation) that essentially contribute to the cancer development. This course aims at giving students an overall view of the complexity of the carcinogenesis that encompasses cooperation between a variety of changes, dysfunctions and pathways. This course includes several topics depicting the involvement of genetic and external factors in the carcinogenesis. It also gives an understanding of the role and balance between distinct suppressors and oncogenes in the angiogenesis and metastasis.
Evaluation of regular participation and active cooperation as well as written examination
Lector: FH-Prof. Dr. Thomas Czerny, Dr.in Elisabeth Riegel
The therapeutic potential of a small molecule drug will be estimated with a variety of cell based test systems. On the one hand the activating potential of the small molecule on a specific pathway (heat shock response pathway) is analysed and on the other hand possible cytotoxic effects are estimated in a concentration dependent manner. A broad variety of assays is provided for the students including luciferase reporter assays, Western blot, qPCR, flow cytometry, ELISA and general viability assays. The students themselves select suitable methods.
consist ofpretest on experiment instructionsperformance in the labprotocols of the experimentsdiscussion of results after the course
practical course with independent performance of the experiments
Lector: Prof.(FH) Mag. Dr. Christoph Wiesner
Students will learn how to isolate natural drugs (small molecules) from plants or how to produce biologics. Course Content also includes different in vitro Screening methods, HCS, HTS (including target-and phenotype-based drug discovery).
written exam 100%
Important methods for the analysis of signalling pathways are applied. In parallel the knowledge about specific pathways is broadened. Applied methods are transient transfection in cell culture, reporter constructs with gfp and luciferase, overexpression of activators/repressors, Western analysis of cellular extracts, in vitro phosphorylation, fluorescence microscopy of labelled proteins, analysis of the cytoskeleton, determination of translational activity and pharmacologic manipulation of the pathways.
combined with the lecture "Signalling Pathways"lab work
Lector: FH-Prof. Dr. Thomas Czerny
Important signalling pathways of the cell (e.g. MAP kinase-, GPCR-, Nuclear Hormone Receptor-, NF-kB-, Jak/Stat-, Wnt-, Hedgehog-, Tgfß-, Apoptosis-, PI3K/Akt- and stress pathways) are presented together with their effects on gene regulation and other functions of the cell. In addition the crosslinks with other pathways are discussed. Techniques for the analysis of signalling pathways are also presented, preparing the students for the practical course, which runs in parallel to the lecture.
lecturesPowerpoint presentations and down-loadssome chapters are discussed
Lector: Doz. Mag. Dr. Wolfgang Sommergruber
Clinical failures and validity of targets, Extracellular signaling (endocrine – paracrine – autocrine; multitype); Mechanisms of signal transduction and the determination of the fate of a cell; Intracellular signal-transduction (signaling by phosphorylation and GTP-binding); PD-1/PD-L1 and CTLA-4 signaling in immune cells; Molecular mechanisms of EMT; Ligand-binding and effector specificity of receptor proteins; Acetylcholin: Same signal can lead to different effects in cells of different tissues; Hormones: Small lipophilic molecules and their intracellular receptors; hydrophilic and lipophilic hormones and their cell-surface receptors; Hormone receptors (retinoid-x-receptor; PR, GR, AR and ER receptors); Hashimoto's thyroiditis, Graves' disease; nuclear receptors; Prostaglandin (PG) Biosynthesis (COX1, 2; COX inhibitors); prostaglandin signal-transduction pathways; Insect and snake venom (PLA2); Prostaglandins in breast cancer and endometriosis (autocrine and paracrine actions of PEG2 and PEF2a; biphasic activation of FGF-9 by PGE2; phagocytic ability of macrophages and PEG2; StAR and aromatase; aromatase inhibitors); G protein-coupled receptors; Ion-channel receptors; Tyrosine kinase-linked receptors; Receptors with intrinsic enzymatic activity; EGFR (mechanisms of EGFR dysregulation; therapeutic concepts, types of biomarkers); Molecular mechanisms of oncogene addiction and clinical resistance; Compensatory pathways in oncogenic kinase signaling and resistance to targeted therapies (EGFR, BRAF, SMO); Dual-specificity phosphatases: Critical regulators with diverse cellular targets; The hedgehog pathway in development and disease; Fusion proteins of ALK and their contribution to tumorigenesis; Tyrosine kinase-linked receptors; Types/mechanisms to die: Immunogenic cell death (ICD);
Written exam short oral presentation (FlipChart + feedback discussion)
Oral presentations with PowerPoint slidesPrinted handouts will be providedShort presentations by students on selected topics (FlipChart)
The timetable for this semester will be provided as detailed information sheets and will be discussed during the first lesson.The students will work on a projekt which they will present at the end of semester at a "workshop".See also below (Objective of the course).
Lector: Dr. Irene Fialka, CMC, Mag. Dr. Manuela Loidl
• Which forms of protection of intellectual property are available? – trademark, industrial design, copyright, utility model, complementary protection certificate, patent• invention vs. innovation?• history of patent rights• Why patent protection?• Patent?– effects of a patent– what can be patented and what ist excluded from patent protection?– what are the prerequisites for patent application/protection? – How to define inventor?– rigths and obligaitons of inventors as employees• From application to patent grant– structure of a patent application– application and granting processes- protective reach and duration– legal measures– fees and costs– Where to apply for a patent• how to protect on an international level and important national differences• Rights of patent owners and legal measures• international agreements (EU, PCT)• Biopatents – legal framework• Freedom to Operate - what does it mean, what for?• Espacenet and how to use it for patent research• patent lawyer - the profession• basics in copyright• basics in industrial design• basics in trademark• strategies and decision making• important agreements– MTAs, CDAs, licensing contracts• Licensing contracts– basic principles– important clauses– Franchise
written exam at the end of the coursemaximum number of points: 33<16,5 (i.e. < 51%) insufficient16,5 - 21 (i.e. 51% bis < 64%) sufficient21,5 – 25 (i.e. 64% bis < 77%) satisfactory25,5 – 30 (i.e. 77% bis < 91%) good 30,5-33 (i.e. ab 91%) excellent
Lecture (with interactive elements)
Lector: Paula Dlugosz, MSc, Dipl.-Ing. (FH) Christine Haider, M.Sc. , Ao. Univ. Prof. Mag. Dr. Wolfgang Mikulits, Ao. Univ. Prof. Mag. Dr. Ernst Müllner, Ao. Univ. Prof. Dr. DI Johannes Nimpf, FH- Prof.in Mag.a Dr.in Marianne Raith, Maike Werning, MSc.
H&E staining and documentation of paraffin-sections of human tumor samplesHuman blood (mononuclear) cells: preparation, assessment, and flow cytometry
permanent observation of active participation, quality of data assessment and documentation
*practical work in small groups of 3-4 students under permanent supervision by lecturers and tutors* specific web-based tutorials produced by lecturer and printed course material is provided
Lector: Ao. Univ. Prof. Mag. Dr. Wolfgang Mikulits, Ao. Univ. Prof. Mag. Dr. Ernst Müllner, Ao. Univ. Prof. Dr. DI Johannes Nimpf, FH- Prof.in Mag.a Dr.in Marianne Raith
I: culture of primary cells, organoids, cell engineering, tissue printingII: hematopoiesis, hematopoietic stem cells, leukemia, leukemia treatmentIII: stem cell transplantation, leukemia stem cells
written exam at the end of the lecture
classical lecture with material prepared by the lecturer
Lector: Mag. Dr. Thomas Dechat, DI (FH) Sabrina Gruber, PhD, Dr. Arabella Meixner, Daniel Wenzel
The aim of this practical course is the experimental work with embryonic stem cells and induced stem cells. Culture conditions, charcaterization assays and embryoid body formation will be established. Gene expression analyses will be perforemd by RT-Rand qPCR.
The grade combines: attendance, motivation, enthusiasm, written report
Lector: Dr. Arabella Meixner
Stem cells have a great potential for organ regeneration. Why are stem cells so special? Which type of stem cells can be used? What kind of potential, how can cells be manipulated and how about the latest news in stem cell research will be discussed.
Lectures with power point presentation
Strategic Management;from vision to strategy;Market analysis using Porter-Model;SWOT as a useful tool to develop strategic options;Product portfolio management (BCG-Model)
Each student: written paper on this topic (approx. 2 Pages) will be evaluated. Topics/tasks will be worked on together with the students.
Lectures with discussions, small peer-exercises
Lector: Andrea Steinbauer, BSc MSc, FH-Prof.in Univ.Doz.in Dr.in Ines Swoboda
In the laboratory the students will deepen their theoretical, immunological knowledge with examples from the field of Allergy. Students learn important immunological methods (ELISA, Western blot, immuno screening of cDNA libraries, isolation of human leukocytes, flow cytometry, cell activation test) and learn how these methods can be used for the isolation and immunological characterization of allergens.
Active participation, protocol
Lector: Univ.Prof. Mag. Dr. Wilfried Ellmeier, Univ.Doz. Ao. Univ.Prof. Dr. Herbert Strobl
The lecture aims to provide an overview about the interaction of the different immune cell subsets under physiological (e.g. during the course of an infection) and under pathophysiological conditions (e.g. immune-mediated diseases such as allergy and autoimmune diseases). In addition, we will discuss concepts of clinical immunology and diagnostic tools and applications.Content discussed by Ellmeier:1) Immediate Hypersensitivity - IgE-dependent immune responses and allergic diseases2) Hypersensitivity disorders3) Immunological tolerance and autoimmunity4) Transplantation immunology5) Regional immunity - gastrointestinal immune system and the microbiome6) Therapeutic approaches to treat immune-mediated diseases
written exam at the end of the lecture (mixture of multiple choice questions and "open" questions)
Lector: Univ.Doz. Dr. Hans-Jürgen Busse, Andrea Steinbauer, BSc MSc
This course will introduce the students to the handling of bacteria and to demonstrate their diversity. In one experiment the dependence of chemo-physical conditions on the success of cultivation of bacteria will be studied and the results will be evaluated. In another experiment bacterial isolates from different human sources will be characterized morphologically and physiologically according to techniques often applied in clinical diagnostics. Furthermore it will be attempted to identify an antibiotic-producing bacterial isolate from soil. Finally, an examination of potable water for the bacterial load will be carried out in dependence to legal regulations
Main criterion is the quality of the protocol but participation during the course may contribute, as well
Learning by doing and observation
Lector: Ao.Univ.Prof. Dr. Dieter Klein, Dr.rer.nat. Christoph Metzner
The course covers the different phases of the viral lifecycle. Additionally, recent publications will be discussed during the course. Following subjects will be presented:History and impact of virusesOverview of the different viral life cyclesViral entry and receptorsViral replicationAssembly and buddingViral maturation
Lecture with discussions
Lector: Univ. Prof. Dr. Franz Allerberger, Univ.Doz. Dr. Hans-Jürgen Busse, Priv. Doz. Dr. Irina Druzhinina, Priv. Doz. Dr. rer. nat. habil. Holger Scholz, FH-Prof.in Univ.Doz.in Dr.in Ines Swoboda
The students get to know the most important human pathogenic bacteria, fungi and parasites. The organizing principles are presented, which are used to investigate the relationship between microorganisms, and the resulting taxonomy will be explained. Furthermore, methods and techniques are presented, which are currently used for the diagnosis of microbes, with a special focus on the molecular diagnostics and molecular typing of highly pathogenic bacterial pathogens.
Multiple Choice Test
Lector: Dr.in Mary Grace Wallis
In seminar lectures the students have prepared in groups, they should present the ethical aspects and their pros and cons relevant to a selected topic. In plenary discussions these ethical aspects are deepened.
Evaluation of oral presentation und resulting discussion
Seminar lectures by students, discussion
In this course the students learn strategies of scientific research. In a small group they develop such a strategy, by designing experiments and work packages which they evaluate according to different criteria like costs, effort, efficiency, .. Finally each group presents its strategy.
Presentation und discussion of the developed strategy
Lector: Univ.-Doz. Dr. Bernhard Fischer, MBA
Overview of the clinical development process of biotechnology-derived molecules and drugs in the Eurpean Community. In addition to planning and performance of general clinical studies, special information for SME-organisations, for Orphan Drug Designation, for Advanced Therapy Products and for "high-risk" drugs will be provided.Overview of the preclinical and clinical development process of biotechnology-derived molecules and drugs.
Written examination at the end of the course.
Lector: FH-Prof. Dr. Thomas Czerny, Dr.in Elisabeth Riegel, Andrea Steinbauer, BSc MSc
Experiments will be performed for genetic manipulation of living organisms and cell culture cells. The program includesBasics of the fish model systemmicroinjection of embryosin situ hybridisation of embryosuse of transgenic lines with inducible expressionmiRNA as a reverse genetics method
Assessment of the work in the lab, written exams at the beginning and end of the lab course and a written summary of the experiments.
Lector: Reinhard Ertl, MSc, Ao.Univ.Prof. Dr. Dieter Klein, Mag.rer.nat. Melanie Korb, Dipl.Biol. Sarah Schlosser
The theoretical part of the lecture will introduce the basic aspects of gene transfers using retroviral vectors. Additionally, different methods for the estimation of the succes of gene transfer will be discussed in detail.During the practical part of the course gene transfer experiments will be performed by the students. Afterwards the sucess of the gene transfer will be estimated using different molecular methods (FACS-analysis, real-time PCR, fluorescence mocroscopy).
Assessment of the attendence and the written protocol
Practical course including a theoretical part
The following topics will be covered during the course:Principles of gene therapyOverview on applications of gene therapyGene transfer methodsMethods for gene tranfer estimationCharacteristics of different viral vector systemsNon-viral vector systemsRetroviral vectorsAdenoviral vectorsAdeno-assoziated viral vectorsOther viral vectorsApplications of gene therapy for different diseasesProblems and perspectives
Written Examination at the end of the lecture
Lector: DI Karl Mechtler, Dr. Peter Pichler
The lecture provides an introduction into the basic principles of proteomics: sample preparation & fractionation (1D and 2D GE, HPLC, CE, SCX RP and affinity chromatography, difficulty of contamination e.g. keratins, SDS, salts). Explanation of the principles of mass spectrometry: ion sources (MALDI, ESI), types of mass spectrometers (TOF, quadrupole, ion trap, FT ICR) and the respective combinations e.g. MALDI-TOF/TOF etc. Resultion R and mass accuracy dm/m (ppm). Improvement of the latter by delayed extraction & reflectron for MALDI-TOF. Isotopic distribution, single and multiple charged ions (ESI). PMF (peptide mass fingerprinting), principles of data base analysis of mass spectra. Collision induced dissociation CID, MS/MS analysis and de novo sequencing. In addition an introduction into the methods of quantitative proteomics, as well as the analysis of post-translational modifications.During the "hands on" lab every student excises a band containg a protein out of a 4-20% SDS-PAGE (Tris/Glycin) gradient gel. Purification, reduction and alkylation of Cysteines, o/n digestion with Trypsin, next day spotting onto a MALDI target, and generation of a PMF mass spectrum with MALDI-TOF and MSMS spectra of the most intense peptides. Subsequently identification of the protein with database search algorithms.
Lab work, lab protocol and written exam.
Lecture, "hands on" lab work, computer lab to learn how to operate commonly used proteomics software (Mascot, Protein Prospector).
The different levels of regulation of gene expression are discussedTranscriptional regulation (transcription in eukaryotes, transcriptional activation, properties of transcription factors)Posttranscriptional regulation (splicing, transport, stability of mRNA, translational control)Effects of chromatin (composition, histone modifications, regulation, epigenetics)Examples from signalling pathways
written exam in the last lecture
lecturesPowerpoint presentations and down-loads
Lector: FH-Prof. Dr. Thomas Czerny, FH-Prof.in Univ.Doz.in Dr.in Ines Swoboda, FH-Prof. Dr. Herbert Wank, FH-Prof. Dr. Paul Watson
During this seminar, the students will present the topics of their Master thesis projects and discuss the chosen strategies and methods.
Presentations; Q & A sessions; independent literature searches.
Capstone Session on Business Management Context:Alignment of the triangle:* Strategic Perspective as Business Driver* derived perspective on implementation through processes* embedded perspective on humans through leadership sessioncreate landscape of relevant knowledge in the sense of LLspecial sessions from guest lecturer on business development and recruiting ..
Evaluation of individual contributions and participation in given classroom discussions and Tasks.
workshop, interactive conversations in groups, peers,
1) Acquire knowledge on selected bioinformatics chapters (Next Generation Sequencing, ChIP-Seq, RNA-Seq) and2) Application of relevant bioinformatics tools for the analysis of associated data
100 % Protocol in which you have to analyse RNA-Seq Data/ ChIP-Seq Data
- Introductions and explanations (lecture)- Exercises using the computer
Lector: Dr. Christian Kössl
The lecture “Biologicals” gives an overview over the most important aspects of biotherapeutics (=biologics) which is the fastest growing type of drug gaining more and more importance. Focus of the lecture are the discovery research of therapeutic concepts enabled by engineering of biologics, bioprocess development of biologicals, and manufacturing aspects.Major differences and therapeutic aspects differing between small molecule drugs and biologics are discussed; examples of major classes of biologics will be presented as case studies.Discovery and engineering of therapeutic monoclonal antibodies will be discussed in more detail as this class of therapeutics reflects the biggest class amongst many other biologicals.Approaches and technologies for biopharmaceutical manufacturing and purification will be discussed; major aspects and challenges of protein analytics and physicochemical characterization of biologics will be highlighted.
Lector: FH-Prof. Dr. Thomas Czerny, Dr. Klaus Rumpel
At the center of this course is the drug and its interaction with target proteins. Methods for determination of protein structures and characterization and quantification of protein ligand interactions are presented. In addition strategies and methods for the optimization of these interactions are discussed (lead optimization, rational design). Furthermore, aspects of pharmacokinetics (ADME, prodrugs) are presented. The underlying principles are demonstrated by selected examples.
Lector: Ao.-Prof. DI Dr. Thomas Kolbe, Univ. Prof. Dr. Thomas Rülicke, Dr.med.vet Christiana Winding-Zavadil
The aim of the lecture is to gain skills and expertise in laboratory animal handling and behavior (with a focus on mouse and rat) and acquisition of techniques for substance application and sampling.Practical training for personnel carrying out procedures on animals according to FELASA B guidelines.
participation and written examination
Demonstration and tutorial
Lector: Univ. Prof. Dr. Thomas Rülicke
The development and current topics of Laboratory animal science as a discipline in biomedical sciences. Laboratory rodent husbandry, hygienic concepts and their monitoring. The principles of the three R’s during planning and implementation of animal experiments.
Lector: Mag. Dr. Gerda Brunhofer-Bolzer
Structure and function of drug targets on the molecular level as well as their role as regulators of cell function, the prodrug strategy, most frequently prescribed drugs for the treatment of human diseases (e.g. background of a disease, mechanism of action, important side effects)
Written examination at the end of the course, evaluation of the tasks provided during the course
Each topic is introduced and necessary information is provided through didactic lectures and e-learning methods. Subsequent lectures focus on the use of this information (e.g. discussion of research papers or research problems, student/poster presentations).
Lector: Dr.phil. Dr. med.univ. Karl-Heinz Huemer
membrane physiology, action potentials, elektrotonic/saltatoric conduction, synapses, important transmitter systems & pharmacological modulation, temporal & spatial integration, pre/postsynaptic inhibitionmotor functions of the spinal chord, basal ganglia, cerebellum and cortex incl changes of lesions in these regionsstructure and function of the autonomic nervous system (peripheral & central coordination) incl effects on important organssensory systems: mechanorecption, pain, equilibrium, smell, tasteCNS: cortex, EEG, activationg systems, sleep, circadian rhythms, learning & memory, language
The seminar deepens the students' knowledge in the field of vaccine development by operating first in-depth literature search on selected topics and then summarizing the knowledge acquired in a presentation and in a written work. Students will actively participate in the presentations of other colleagues, in which they ask questions and offer constructive criticism.
Presentation, discussion, manuscript
Seminar (literature search, presentation, discussion, manuscript)
Lector: Dr. Shailesh Dewasthaly
The course will begin with general product development in the field of pharmaceutical world. From product development, intricacies involving vaccine product development will be discussed. Detailed discussions on some approved/licensed vaccines will also be done. Some important aspects of vaccine production cGMP will also be a part of the lecture. Since most of the above discussions will be from an 'industry perspective' one lecture will be held to describe the 'regulatory authority perspective'.
Seminar assignment and presentation
Normal interactive lectures with power point slides.
Lector: Julia Pointner, PhD, FH- Prof.in Mag.a Dr.in Marianne Raith, Assoc. Prof. Priv.-Doz. Dr. Gernot Schabbauer
The present lecture is sectioned in two major topics: hematology and vascular biology/pathology.HEMATOLOGY1. erythrocytes: structure, cytoskeleton, hemoglobin, gas-exchange, degradation of erythrocytes, iron metabolism, blood types.2. leukocytes: morphological leukocyte determination in light microscopy3. thrombocytes: structure, activation, adhesion, aggregation, interaction with cells or ECM4. hemostasis: coagulation, cell-based model of hemostasis, fibrinolysis, inhibitors, coagulations tests5. laboratory diagnostics: sample preparation, plasma/serum, clinical chemistry, red/white blood cell counts, serology6. hematological disorders: reactive disorders of erythrocytes/leukocytes/thrombocytes, malfunction of hemostasisVASCULAR BIOLOGY1. overview of the vascular system: definitions, structure, blood/lymph-system2. development of blood vessels: vasculogenesis, angiogenesis, role of specific angiogenic growth factors3. the endothelium: biology of endothelial cells, structure of endothelium, types of endothelium4. features of the endothelium: regulation of vascular tone, endothelium and cell adhesion, endothelial dysfunctionVASCULAR PATHOLOGY1. the role of the endothelium in acute inflammatory response: systemic and local disease - e.g. sepsis and acute lung injury2. atherosclerosis as a chronic inflammatory process: risk factors, lipid metabolism, atherogenesis, pathophysiology of instable lesions/plaque rupture, animal models of atherosclerosis research
The written exam consists of 40 single choice questions and 3 general questions (one for each topic of the lecture). Grades are based on the average score of participants.
Lecture (Power-Point presentations, board), recent reviews.
Lector: FH-Prof. Dr. Paul Watson
In the Master thesis seminar, students present the topic of their thesis projectand give a status report on their progress. They will also actively participate in the presentations of other speakers (asking questions, constructive criticism, etc.).
Undertaking independent research on a scientific topic and then writing a Master thesis.
Semester datesWinter semester: 6th September 2017 to 2nd February 2018Summer semester: 19th February to 13th July 2018Number of teaching weeks18 per semester
TimesMon. to Fri. all day; some vocational subjects also held on Sat.
Language of instructionEnglish
As a specialist, you will mainly be engaged in research and development during your future employment. You can undertake a life science PhD at an Austrian or international university. You are qualified to lead lab or research groups. In addition, you have the entrepreneurial know-how to set up your own start-up. You will work in the following industries and sectors:
In the disciplines of biotechnology, food biotechnology, medical-technical services, molecular biology or biology with a focus on genetics/microbiology, pharmacy, medicineWith at least> 20 ECTS credits in chemistry (general, analytical chemistry and physical chemistry, organic and bioorganic chemistry, biochemistry), > 25 ECTS credits in biology (molecular biology & genetics, cell biology, microbiology, genomics) > and at least 6 ECTS credits in mathematics, statistics, informatics. This is valid for those degree programs which have already implemented the ECTS system. In exceptional cases, the University Council will make a joint decision with the head of the academic section.
Equivalence is determined by international agreements, validation or in individual cases a decision by the head of the academic section.
There are 50 places available in the master's degree program in Molecular Biotechnology each year. The ratio of places to applicants is currently around 1:3.
To apply you will require the following documents:
English as a first language or one of the following certificates:> Test of English for International Communication (IELTS) 7-9> Cambridge English Advanced (CAE)> Cambridge English Proficiency (CPE)> Test of English for International Communication (TOEIC) 880-990> Test of English as a Foreign Language, internet-based test (TOEFLiBT ) 110-120> UNICERT (III)Please note that the examinations have to be passed at the time of application and all IELTS, TOEIC and TOEFL scores must be valid.
It is not possible to save incomplete online applications. You must complete your application in one session. Your application will be valid as soon as you upload all of the required documents and certificates. In the event that some documents (e.g. references) are not available at the time you apply, you may submit these later via email, mail or in person by no later than the start of the degree program.
The selection process consists of a written test to assess the knowledge and understanding of the applicant at the bachelor level and an interview with the selection committee.
You will complete a multiple choice test to assess your knowledge of biology, molecular biology, cell biology, chemistry, mathematics, logic, and English.
Afterwards, you will undergo an interview with the selection committee in which you will have the opportunity to present your career, your motivation, your studies and your professional goals.
Head of Department Applied Life Sciences, Head of Degree Program Molecular Biotechnology T: +43 1 606 68 77-3501 email@example.com
Academic Staff, "Stadt Wien" Endowed Professorship for Cell-Based Test Systems
We work closely with numerous biotech companies, universities, such as the University of Vienna, and research institutes and have a strong international network. This guarantees you strong contacts for a semester abroad, participation in research and development activities or your professional career. You can find information about our cooperation activities and much more at Campusnetzwerk. It's well worth visiting the site as it may direct you to a new job or interesting event held by our cooperation partners!