Lecture contents

Construction of various simple control circuits and comparison of different control strategies.
Each student builds her own control circuit using an Arduino starter kit, puts them into operation and studies their behaviour.

Assessment methods

Participation and protocol, final discussion.

Teaching methods

Experiments with an Arduino starter kit and a laptop.

Language

German

Lecture contents

Overview on the biogas technology for energy recovery from renewable resources in combination with Algae technology for the development of biorefinery concepts.
A focus will be put on process regulation and application fields for both technologies.

Assessment methods

written exam

Teaching methods

presentation

Lecture contents

introduction to control theory
Controllers (PID-control, two-position control, cascade control,…)
requirement to control loops (performance, stability)
control design, determination of controller paameters
control of bioreactors (temperature, pH, pO2)
practical design of flow and level control

Assessment methods

written exam

Teaching methods

lecture
exercises
practical training

Language

German

Lecture contents

After the introduction, where the basic concepts and principles of bioprocess engineering are explained, the main bioreactor types and operation modes are presented. In the following section the kinetics of bioprocesses together with the underlying equations and graphs are outlined. Heat and mass transfer correlations, which are essential to be familiar with - especially for the design of bioreactors, are dealt in the following section. The characterization of various bioreactor types including enzyme reactors as weell as the upscaling principles are main topics of this lecture. Finally the basics of the sterilization technology and the design of SIP procedures are elucidated.
The understanding as well as the benefit of the presented model equations for the particular unit operations are shown by some selected examples.

Assessment methods

Two written intermediate exams and a final test.

Teaching methods

The teaching is based on the following concept:
First the scientific principles involved in a specific unit operation within biochemical engineering together with their practical application are elucidated. After a thorough discussion on the limitations of the respective Mathematical Model its practical value is shown by some examples.

Lecture contents

The course addresses the technology of manufacturing formulations for the parenteral application as well as methods of quality control according to the rules of the European and international pharmacopeia. In this context, well established formulations and innovative products will be presented and special biopharmacutical aspects will be discussed.

Assessment methods

written examination

Teaching methods

lecture

Language

German

Lecture contents

This course mainly presents biological and biotechnological manufactured products with the focus on application of innovative drugs (monoclonal antibodies, vaccines, gene therapy and cellular therapies) without overlooking the importance of plasma-derived products. Fundamentals of drug development also from a regulatory and economic point of view, including clinical development and the associated challenges and aspects of tolerability and effectiveness in selected diseases (including so-called orphan diseases) are discussed. The aim is to gain an understanding of “patient-tailored” approaches compared with historical, less unspecific treatments using examples from oncology. With in-depth examples of individual innovative therapeutic agents such as AAV9-based gene therapy, immune checkpoint inhibitors for tumor diseases and others, a holistic view is to be given from the perspective of developers and manufacturers on the one hand, but also patients. Basics of genetics and immunology with regard to their application in the context of modern, biological therapeutic approaches and vaccines are outlined. The relevance for practical use is considered from an economic, medical point of view, but also from the point of view of the health system payers (key players in the biotech industry, vaccination programs, biotech companies, licensing authorities, etc.). An outlook for activities in the biotech and pharmaceutical industry is given.

Assessment methods

final exam

Teaching methods

Lecture

Lecture contents

Terminology; overview regarding the market situation
- Biotechnological processes for the production of biobased materials and/or their monomeric precursors:
Feedstocks for fermentation and their availability;
Chemical derivatisation/synthesis of bioplastics; processing and moulding (especially thermoplastic moulding, e.g. extrusion and injection moulding); examples for applied moulding processes

Assessment methods

Presentations

Teaching methods

lecture and practice

Language

German

Lecture contents

1. Part
basic concepts of differential and integral calculus
solution of differential equation
linear differential equations
2.Part
Tutorial

Assessment methods

participation, exercises

Teaching methods

lecture

Lecture contents

Anwendung spezieller Verfahren der Risikoanalyse:

Fehlerbaumanalyse
Ereignisbaumanalyse und Layer of Protection Analyse
HACCP
SWIFT (Structured What-If) Analysis, Checklisten

Assessment methods

written exam (risk Analysis examples)

Teaching methods

Presentation of techniques, common acquirement of working examples.

Lecture contents

The course covers the foundation of validation, regulatory requirements and guidelines, equipment qualification (DQ, IQ, OQ, PQ), risk analysis, method validation, process validation, cleaning validation and sterilization/sanitization validation. Focusing of the preparation of associated documentation through validation projects will be included in practical detail.

Assessment methods

Concurrent performance assessment via blended learning tasks and permanent review of content already bespoken incl. solving examples to demonstrate the ability to apply the content practically.
If after the last lesson before the written final exam less than 60 % of the required performance were provided in addition, following directly the written final exam an oral examination has to be performed. This will be communicated the students affected in an appropriate manner (via Moodle, by mail).

Written Final Exam (multiple choice, text questions and sample calculations)

Weighting of the final grade:
Written Exam 60% and blended learning tasks 40% (each part must be completed with a positive grade)

Teaching methods

Lecture (as distance learning via Zoom) and blended learning
The lecture slides and additionally the comments of the lecturer during the lecture are the basis of the course content. Those will be additionally completed with the content (documents, videos, podcasts, internet links, ...) for the blended learning tasks.
The sum of this all is relevant for the blended learning tasks (i.e. permanent progress check) and the written final exam.

Language

German-English

Lecture contents

1 Thermodynamics
1.1 Introduction
1.2 Change in State
1.3 The First Law of Thermodynamics
1.4 Thermal calculations
1.5 The Second Law of Thermodynamics
1.6 Work - Fluid Systems
1.7 Exergy
1.8 Heat Transfer
2 Technical Heat Transfer

Assessment methods

Written examination

Teaching methods

Lecture

Lecture contents

Basic considerations in Risk Management
Terminology in the field of risk analysis;
Typical fields of application and legal aspects;
Process safety incidents;
Risk assessment (qualitativ, quantitive, semi-quantitative);
Analysis methodologies:
FMEA
HAZOP
Fault Tree Analysis (Basics)

Assessment methods

written exam

Teaching methods

Presentation, common acquirement of working examples.

Language

German

Lecture contents

Cleaning of surfaces, that are touched by products
Matrices of processes and tools
Analysis and planning of cleaning validation
Exercise example for cleaning and cleaning validation at a fermenter or a similar processing unit

Assessment methods

Continous assessments throughout the course

Teaching methods

After an introductory course concerning theory and experience of cleaning, as well as the regulatory framework, an exercise course with a fermentation equipment is following.

Language

German-English

Lecture contents

General aspects of Downstreamprocessing in the environement of a biotechnology production Unit operations of DSP (Centrifugation, precipitation, filtration, ultrafiltration, chromatographic methods). Dimensional analysis of unit operation with simple models.

Assessment methods

Written examination

Teaching methods

Lecture with sample calculation

Language

German

Lecture contents

Schemes / set up of down stream processes for recombinant proteins
Process design and dimensioning

Assessment methods

Written exam about theoretical background and calculation of processes

Teaching methods

Interactive Lecture with presented process calculations
Optional homework

Language

German

Lecture contents

1 Introduction Thermodynamic Processes
1.1 Cycles
1.2 Two-Phase Systems - Steam
2 Refrigeration
3 Technical Energy Systems
3.1 Introduction
3.2 The Heat Pump
3.3 Renewable Energy

Assessment methods

Written examination

Teaching methods

Lecture

Language

German

Lecture contents

Module 1. Overview and review of enzyme technology and definition of technical terms
Module 2. Biochemical basics: structure and function of proteins
Module 3. Enzyme production (fermentation, purification and formulation)
Module 4. Enzyme modifications (aims, genetic engineering, immobilisation techniques)
Module 5. Enzyme kinetics (reaction mechanisms and catalytic constants)
Module 6. Biochemical reaction engineering (reactors, process control)
Module 7. Enzymes in industry (bulk- and fine chemicals, antibiotics)
Module 8. Enzymes in analytical applications (diagnostics, enzyme assays, biosensors)
Module 9. Questions and preparation for the examination

Assessment methods

Written exam

The written exam of enzyme technology consists of 6 questions (including 1 calculation example) covering all presented topics, the information on the slide scripts and the calculated examples. The maximum number of achievable points is 100 (the number of points for an individual question is indicated on the questionaire). Correlation of points ad grades: 93+ points: sehr gut (1); 85+ points: gut (2); 75+ points: befriedigend (3); 60+ points: genügend (4); below 60 points: nicht genügend (5).

Teaching methods

Lecture, brainstorming and discussion. Case studies and calculations will be worked out together.
Questions are appreciated at any time. A slide scripts for each lecture will uploaded approx. 1 week before the lecture. Please prepare before the lecture for maximum benefit.
The first modules of the lecture will be given via Zoom (Zoom-Meeting https://bokuvienna.zoom.us/j/7532067349), the last lecture and the examination will be held in a lecture room.

Language

German

Lecture contents

The bioprocess laboratory involves the production process. It consists of designing the process to harvesting and filtration.
The students will learn the production of the “Green Fluorescent Protein” with E. coli.

Assessment methods

report and presentation

Teaching methods

Practical course

Language

German-English

Lecture contents

The course comprises the manufacturing of well established application forms, e.g. granules, pellets, tablets, capsules or parenterals and inhalants as well as the production and development of innovative products. In addition, biopharmaceutical aspects of the enhancement of efficacy of drugs will be discussed. A main topic of the practical course is the quality control according to the rules of the European Pharmacopoeia.

Assessment methods

written examination

Teaching methods

lecture and practical course

Language

German-English

Lecture contents

General topics of statistics:
exploratory data analysis
basics of statistical inference (hypothesis testing)
statistical modeling, selection of models

CAUTION: applied example are done in the Tutorium alongside this lecture due to time restraints. Attending the tutorium is highly recommended.

Assessment methods

Homework, in class Participation, final examination

Teaching methods

Applied practice with "R"

Language

German

Lecture contents

Logic and objectives of statistical comparison studies, basic inferential statistics and experimental designs, possible errors in the statistical data assessment, sample size determination, interpretation of P-values, r-squares and residuals, basic variance decomposition methods, regression, etc.

Assessment methods

Test mode:
Exercises to be performed within the lecture sequence. Written test after lecture is finished. The test will consist of a combination of multiple-choice questions and application examples with open questions. Working with the software will be part of the exercises, but not part of the test!
The grading is based to each one-third on the performance of the exercise and the two parts of the written test. Attendance and contribution is recognized whenever the evaluation decision is marginal. In case the test is failed, the repeat test will always be held as an oral exam.

Teaching methods

Lecture with embedded practical exercises. The content will be taught in training locations enabling access to statistics software provided. Work on exercise examples can be done on individual time management.

Language

German

Lecture contents

This course is held in German. The description is therefore also restricted to German.

Assessment methods

This course is held in German. The description is therefore also restricted to German.

Teaching methods

This course is held in German. The description is therefore also restricted to German.

Language

German

Lecture contents

Plant Engineering: Phases of Engineering and Construction of facilities. Explanation of enginering issues and engineering steps. Arrangement of equipments, utilities and site function for ideal material and personal flows, by taking the cleanroom classifications unter consiteration. Dimensioning of rooms sizes and definition of quality standards of rooms. Listing of necessary site functions for utilities.
Mechanical Process Design: Basic needs and quality standards for equipments, pipes, valves and instruments (design, form, materials)

Assessment methods

written examination after the course

Teaching methods

Lecture

Language

German

Lecture contents

Good Manufacturing Practice (GMP) forms a quality framework for the production of pharmaceutical and biotechnological products. Plant Hygiene represents a central pillar of GMP, both in the way of general principles for avoiding adventitious product contamination and through specific forms of implementation and instruments.

Assessment methods

Concurrent performance assessment via blended learning tasks and permanent review of content already bespoken incl. solving examples to demonstrate the ability to apply the content practically.
If after the last lesson before the written final exam less than 60 % of the required performance were provided in addition, following directly the final exam an oral examination has to be performed. This will be communicated the students affected in an appropriate manner (via Moodle, by mail).

1st test date: Written final exam (multiple choice, formulated questions and calculation examples).
Generally, further dates (not exam attempts!) are conducted as oral exams.
The test modality will be announced with the test date.

Weighting of the final grade:
Final Exam 60% and blended learning tasks 40% (each part must be completed with a positive grade)

Teaching methods

Lecture (WS20/21 as distance learning via Zoom) and blended learning
The lecture slides and additionally the comments of the lecturer during the lecture are the basis of the course content. Those will be additionally completed with the content (documents, videos, podcasts, internet links, ...) for the blended learning tasks.
The sum of this all is relevant for the blended learning tasks (i.e. permanent progress check) and the final exam.

Language

German-English

Lecture contents

This course willl convey concepts and requirements for biological safety, as well as occupational health and safety, as covered in EN 45000.
In this context the course will include a discussion of biological risk, followed by related and required measures measures as defined by the risk classes and the austrian VbA.

Assessment methods

Final Exam

Teaching methods

Lectured Course

Language

German-English

Lecture contents

"hands-on" priciples in business administration
Development of a business plan

Assessment methods

preparation & presentation of a business plan

Teaching methods

lecture, Workshop

Language

German

Lecture contents

Brewing at a Craft Beer Brewery:
> Recipe design
> Scale up 50L -> 10hL and comparison
> QA/QC of brewing process
> Filling - KEGs and bottles
> Marketing

Assessment methods

Protocol

Teaching methods

practical course

Lecture contents

The Entrepreneur

How do new things develop?
Recipies for success?

What is an enterprise?
Systems theory perspective

What is management?
Entrepreneur versus Manager:
Tasks
Character

The idea
The Business Model
The Business Plan

The ideal Leader.
Basics of Management.
Tasks of Managers.
Management Tools.

Assessment methods

Oral

Teaching methods

Lecture & Workshop

Language

German

Lecture contents

Short introduction: Products, expression systems, markets
Metabolic Engineering: Aims, Prerequisites, Methods
Optimising Product or Production?
Focus Biomedicine: Antibody – Vaccine - Gene therapy vector
Examples from recent publications
Bottlenecks in Production/Upscaling
Mini seminar on Metabolic Engineering on a real-life example: „ Glycosylphosphatidylinositol-Protein Production for VLP vaccines – Assessing different strategies“

Assessment methods

Final Exam

Teaching methods

Lecture - e-learning - mini-seminar - discussion

Language

German-English

Lecture contents

Introduction to eukaryotic (mammalian) cell culture
Basic Methods: Thawing, Splitting, Seeding, Harvesting, Freezing,
Transfection methods: Co-precipitation and lipofection
Influence of e.g. different plasmid backbones or different host cell lines on product
Analysis: Fluorometric, cytotoxicity, protein content (specific vs. total)

Assessment methods

Continuous assessment of course work/protocol

Teaching methods

Lecture, experimentation, discussion

Language

German-English

Lecture contents

Protective rights; Reading patent documents; scope of protection; novelty, state of the art; inventive step; further requirements of patentability; patent application procedure; international patent laws and treatys; patent licensing;

Assessment methods

written tests at the beginning of the lecture units; homework problem

Teaching methods

Lecture

Language

German

Lecture contents

Structure of statistical designs for more than two factors, differences between individual designs with regard to extent, output and results of various experimental designs. Analysis of experiments by using t-statistics and the General Linear Model (GLM).

Assessment methods

Test mode:
Exercises to be performed within the lecture sequence. Written test after lecture is finished. The test will consist of a combination of multiple-choice questions and application examples with open questions. Working with the software will be part of the exercises, but not part of the test!
The grading is based to each one-third on the performance of the exercise and the two parts of the written test. Attendance and contribution is recognized whenever the evaluation decision is marginal. In case the test is failed, the repeat test will always be held as an oral exam.

Teaching methods

Lecture with embedded practical exercises. The content will be taught in training locations enabling access to statistics software provided. Work on exercise examples can be done on individual time management.

Lecture contents

In addition to the different tasks involved in the project management of biotechnological plants, which include process engineering as well as supply engineering and buildings, topics such as fast track, sustainability or risk prevention are decisive factors for the success of projects.

Assessment methods

written exam

Teaching methods

Lecture

Lecture contents

Water, Potable Water, Purified Water, Methodes of Purification, Maintenance, Equipment for measuring parameters

Assessment methods

Attendance and active participation

Teaching methods

lecture with slides, lecture notes

Lecture contents

Terms and overview of processes for microbial inactivation
Processes of moist heat inactivation, as well as chemical and thermal disinfection
Predictive calculation models

Assessment methods

written exam

Teaching methods

Lectured course

Language

German-English

Lecture contents

Preparation for the master´s degree examination

Assessment methods

Presentation with assessment of the master´s degree thesis and general examination

Teaching methods

-

Lecture contents

The content of this course is the writing of a diploma thesis.

Assessment methods

The "written diploma thesis" constitutes the result of the quality of the works conducted. For this reason, the assessment is based on the quality of the research as well a on the written presentation.

Teaching methods

The diploma thesis has to be written in consultation with the FH supervisor and beforehand has to be approved by the head of the academic section.

Lecture contents

In this class each student has to give a scientific presentation of his or her diploma thesis as preparation for the diploma examination

- What has to be considered when presenting scientific work?

- Give and receive feedback.

Assessment methods

Assessment of the given presentation (structure, slide deck, presentation style, timing).

Teaching methods

Presentation

Language

German